Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1560282..1560759 Replicon chromosome
Accession NZ_CP029084
Organism Staphylococcus aureus strain AR464

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag CSC49_RS07990 Protein ID WP_000052076.1
Coordinates 1560282..1560470 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CSC49_RS07995 Protein ID WP_001059690.1
Coordinates 1560499..1560759 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC49_RS07960 1556272..1556793 + 522 WP_000824479.1 hypothetical protein -
CSC49_RS07965 1557134..1557820 + 687 WP_001622483.1 thermonuclease family protein -
CSC49_RS07970 1558177..1558377 + 201 WP_001059082.1 cold-shock protein -
CSC49_RS07975 1558874..1559092 - 219 WP_000005884.1 hypothetical protein -
CSC49_RS07980 1559165..1559437 - 273 WP_001004400.1 hypothetical protein -
CSC49_RS07985 1559525..1560094 - 570 WP_001106662.1 hypothetical protein -
CSC49_RS07990 1560282..1560470 - 189 WP_000052076.1 hypothetical protein Toxin
CSC49_RS07995 1560499..1560759 - 261 WP_001059690.1 hypothetical protein Antitoxin
CSC49_RS08000 1561100..1561303 + 204 WP_000145160.1 sterile alpha motif-like domain-containing protein -
CSC49_RS08005 1561300..1561536 - 237 WP_000368687.1 hypothetical protein -
CSC49_RS08010 1561760..1562341 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
CSC49_RS08015 1562414..1563031 - 618 WP_000255550.1 LysE/ArgO family amino acid transporter -
CSC49_RS08020 1563187..1563681 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
CSC49_RS08025 1564080..1564502 - 423 WP_000974451.1 organic hydroperoxide resistance protein -
CSC49_RS08030 1564650..1565366 + 717 WP_000150033.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(81-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T104781 WP_000052076.1 NZ_CP029084:c1560470-1560282 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T104781 NZ_CP029084:c1560470-1560282 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT104781 WP_001059690.1 NZ_CP029084:c1560759-1560499 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT104781 NZ_CP029084:c1560759-1560499 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References