Detailed information of TA system TA104780

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 1532159..1532688
• Replicon: chromosome
• Accession: NZ_CP029084
• Organism: Staphylococcus aureus strain AR464

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: K7ZRX6
• Locus tag: CSC49_RS07835
• Protein ID: WP_001103939.1
• Coordinates: 1532371..1532688 (+)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: X5IY59
• Locus tag: CSC49_RS07830
• Protein ID: WP_001058494.1
• Coordinates: 1532159..1532368 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSC49_RS07795	1528489..1528953	+	465	WP_001085185.1	SsrA-binding protein SmpB	-
CSC49_RS07805	1529516..1530622	-	1107	WP_000149511.1	site-specific integrase	-
CSC49_RS07810	1530612..1531415	-	804	WP_000358990.1	helix-turn-helix domain-containing protein	-
CSC49_RS07815	1531551..1531754	+	204	WP_001045296.1	transcriptional regulator	-
CSC49_RS07820	1531790..1532008	+	219	WP_000163544.1	helix-turn-helix domain-containing protein	-
CSC49_RS07825	1532020..1532166	+	147	WP_000784885.1	hypothetical protein	-
CSC49_RS07830	1532159..1532368	+	210	WP_001058494.1	hypothetical protein	Antitoxin
CSC49_RS07835	1532371..1532688	+	318	WP_001103939.1	DUF1474 family protein	Toxin
CSC49_RS07840	1532752..1533621	+	870	WP_001002717.1	primase alpha helix C-terminal domain-containing protein	-
CSC49_RS07845	1533638..1535095	+	1458	WP_000390453.1	virulence-associated E family protein	-
CSC49_RS07850	1535396..1535758	+	363	WP_001039170.1	hypothetical protein	-
CSC49_RS07855	1535760..1536044	+	285	WP_000998185.1	hypothetical protein	-
CSC49_RS07860	1536041..1536682	+	642	WP_001019808.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12547.17 Da
• Isoelectric Point: 5.0161

>T104780 WP_001103939.1 NZ_CP029084:1532371-1532688 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFGELIQKF
HEIEKASSENFGEVSDDAQKLKITE

Nucleotide

• Length: 318 bp

>T104780 NZ_CP029084:1532371-1532688 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACATGTGTACTTAAAAGAATTCGGTGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGTATCAGATGACGCACAAAAATTAAAAATCACAGAGTAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8268.31 Da
• Isoelectric Point: 4.3718

>AT104780 WP_001058494.1 NZ_CP029084:1532159-1532368 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNSIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT104780 NZ_CP029084:1532159-1532368 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACAGAATATGTTAATAGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: K7ZRX6

Antitoxin

• AlphaFold DB: X5IY59