Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 1172179..1172702 Replicon chromosome
Accession NZ_CP029082
Organism Staphylococcus aureus strain AR465

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag CSC50_RS06035 Protein ID WP_000074049.1
Coordinates 1172436..1172702 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag CSC50_RS06030 Protein ID WP_000587616.1
Coordinates 1172179..1172436 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC50_RS06010 1168676..1169425 - 750 WP_000072461.1 CPBP family intramembrane metalloprotease -
CSC50_RS06015 1169620..1171197 + 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
CSC50_RS06020 1171365..1171820 - 456 WP_000732076.1 DUF1307 domain-containing protein -
CSC50_RS06030 1172179..1172436 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CSC50_RS06035 1172436..1172702 + 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
CSC50_RS06040 1173057..1174133 + 1077 WP_001076673.1 M42 family metallopeptidase -
CSC50_RS06045 1174381..1175043 + 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
CSC50_RS06050 1175036..1175812 + 777 WP_000072149.1 iron export ABC transporter permease subunit FetB -
CSC50_RS06055 1176208..1177395 + 1188 WP_000026189.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T104757 WP_000074049.1 NZ_CP029082:1172436-1172702 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T104757 NZ_CP029082:1172436-1172702 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAGGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT104757 WP_000587616.1 NZ_CP029082:1172179-1172436 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT104757 NZ_CP029082:1172179-1172436 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References