104756

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 28641..29118 Replicon chromosome
Accession NZ_CP029082
Organism Staphylococcus aureus strain AR465

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag CSC50_RS00395 Protein ID WP_000052076.1
Coordinates 28930..29118 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CSC50_RS00390 Protein ID WP_001059690.1
Coordinates 28641..28901 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC50_RS00355 24034..24750 - 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -
CSC50_RS00360 24898..25320 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
CSC50_RS00365 25719..26213 + 495 WP_000569883.1 GNAT family N-acetyltransferase -
CSC50_RS00370 26368..26985 + 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
CSC50_RS00375 27058..27639 - 582 WP_001140693.1 phosphoglycerate mutase family protein -
CSC50_RS00380 27864..28100 + 237 WP_000349581.1 hypothetical protein -
CSC50_RS00385 28097..28300 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
CSC50_RS00390 28641..28901 + 261 WP_001059690.1 hypothetical protein Antitoxin
CSC50_RS00395 28930..29118 + 189 WP_000052076.1 hypothetical protein Toxin
CSC50_RS00400 29306..29875 + 570 WP_001106658.1 hypothetical protein -
CSC50_RS00405 29963..30247 + 285 WP_001004399.1 hypothetical protein -
CSC50_RS00410 30309..30527 + 219 WP_000005886.1 hypothetical protein -
CSC50_RS00415 31019..31219 - 201 WP_001059082.1 cold-shock protein -
CSC50_RS00420 31576..32262 - 687 WP_000141557.1 thermonuclease family protein -
CSC50_RS00425 32603..33124 - 522 WP_000824482.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T104756 WP_000052076.1 NZ_CP029082:28930-29118 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T104756 NZ_CP029082:28930-29118 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT104756 WP_001059690.1 NZ_CP029082:28641-28901 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT104756 NZ_CP029082:28641-28901 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References