Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2587138..2587652 Replicon chromosome
Accession NZ_CP029080
Organism Staphylococcus aureus strain AR466

Toxin (Protein)


Gene name TsdT Uniprot ID A0A0U1MQX5
Locus tag CSC51_RS13350 Protein ID WP_000581795.1
Coordinates 2587138..2587347 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0U1MQV0
Locus tag CSC51_RS13355 Protein ID WP_000138930.1
Coordinates 2587359..2587652 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC51_RS13330 2582646..2584004 - 1359 WP_000611479.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
CSC51_RS13335 2584019..2585089 - 1071 WP_108703221.1 D-alanine--D-alanine ligase -
CSC51_RS13340 2585407..2586609 + 1203 WP_001109939.1 rod shape-determining protein RodA -
CSC51_RS13345 2586873..2587010 - 138 WP_000828354.1 hypothetical protein -
CSC51_RS13350 2587138..2587347 - 210 WP_000581795.1 heavy-metal-associated domain-containing protein Toxin
CSC51_RS13355 2587359..2587652 - 294 WP_000138930.1 copper-sensing transcriptional repressor CsoR Antitoxin
CSC51_RS13360 2587818..2589302 + 1485 WP_000571562.1 cardiolipin synthase -
CSC51_RS13365 2589330..2589977 + 648 WP_001187625.1 HD domain-containing protein -
CSC51_RS13375 2590527..2591399 - 873 WP_000725802.1 membrane protein insertase YidC -
CSC51_RS13380 2591485..2592126 - 642 WP_000483162.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7842.83 Da        Isoelectric Point: 4.3869

>T104755 WP_000581795.1 NZ_CP029080:c2587347-2587138 [Staphylococcus aureus]
MIHQNTIYTAGIETKEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T104755 NZ_CP029080:c2587347-2587138 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAAAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATTGATGGTCAAGTAACGGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11169.81 Da        Isoelectric Point: 6.2242

>AT104755 WP_000138930.1 NZ_CP029080:c2587652-2587359 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVKAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT104755 NZ_CP029080:c2587652-2587359 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAAAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CATTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U1MQX5

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1MQV0

References