Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1312985..1313462 Replicon chromosome
Accession NZ_CP029080
Organism Staphylococcus aureus strain AR466

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag CSC51_RS06640 Protein ID WP_000052076.1
Coordinates 1312985..1313173 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CSC51_RS06645 Protein ID WP_001059690.1
Coordinates 1313202..1313462 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC51_RS06610 1308975..1309496 + 522 WP_000824479.1 hypothetical protein -
CSC51_RS06615 1309837..1310523 + 687 WP_001622483.1 thermonuclease family protein -
CSC51_RS06620 1310880..1311080 + 201 WP_001059082.1 cold-shock protein -
CSC51_RS06625 1311577..1311795 - 219 WP_000005875.1 hypothetical protein -
CSC51_RS06630 1311868..1312140 - 273 WP_001004400.1 hypothetical protein -
CSC51_RS06635 1312228..1312797 - 570 WP_001106662.1 hypothetical protein -
CSC51_RS06640 1312985..1313173 - 189 WP_000052076.1 hypothetical protein Toxin
CSC51_RS06645 1313202..1313462 - 261 WP_001059690.1 hypothetical protein Antitoxin
CSC51_RS06650 1313803..1314006 + 204 WP_000145160.1 sterile alpha motif-like domain-containing protein -
CSC51_RS06655 1314003..1314239 - 237 WP_000368687.1 hypothetical protein -
CSC51_RS06660 1314463..1315044 + 582 WP_204161554.1 phosphoglycerate mutase family protein -
CSC51_RS06665 1315117..1315734 - 618 WP_000255550.1 LysE/ArgO family amino acid transporter -
CSC51_RS06670 1315892..1316386 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
CSC51_RS06675 1316785..1317207 - 423 WP_000974451.1 organic hydroperoxide resistance protein -
CSC51_RS06680 1317355..1318071 + 717 WP_000150033.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T104750 WP_000052076.1 NZ_CP029080:c1313173-1312985 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T104750 NZ_CP029080:c1313173-1312985 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT104750 WP_001059690.1 NZ_CP029080:c1313462-1313202 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT104750 NZ_CP029080:c1313462-1313202 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References