Detailed information of TA system TA104738

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2683941..2684550
• Replicon: chromosome
• Accession: NZ_CP029066
• Organism: Enterococcus mundtii strain Pe103

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: DDJ96_RS12800
• Protein ID: WP_010734231.1
• Coordinates: 2684362..2684550 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: V5XTD1
• Locus tag: DDJ96_RS12795
• Protein ID: WP_010734232.1
• Coordinates: 2683941..2684327 (-)
• Length: 129 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DDJ96_RS12775	2679715..2680350	-	636	WP_010734236.1	1-acyl-sn-glycerol-3-phosphate acyltransferase	-
DDJ96_RS12780	2680482..2681216	+	735	WP_010734235.1	tRNA1(Val) (adenine(37)-N6)-methyltransferase	-
DDJ96_RS12785	2681206..2681493	+	288	WP_010734234.1	GIY-YIG nuclease family protein	-
DDJ96_RS12790	2681615..2683546	-	1932	WP_010734233.1	acetyltransferase	-
DDJ96_RS12795	2683941..2684327	-	387	WP_010734232.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
DDJ96_RS12800	2684362..2684550	-	189	WP_010734231.1	type II toxin-antitoxin system HicA family toxin	Toxin
DDJ96_RS15555	2686076..2686222	-	147	WP_155237725.1	hypothetical protein	-
DDJ96_RS12815	2686472..2687347	-	876	WP_010734230.1	YitT family protein	-
DDJ96_RS12820	2687555..2689321	-	1767	WP_010734229.1	aspartate--tRNA ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2672082..2687347	15265

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-62)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (5-101)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 6983.18 Da
• Isoelectric Point: 11.0565

>T104738 WP_010734231.1 NZ_CP029066:c2684550-2684362 [Enterococcus mundtii]
MPMTIREAEKLLKDAGFVEVKGGKGSHRKFTKKDHPRPVILTSHSKELSRRVEDSVRKAVGI

Nucleotide

• Length: 189 bp

>T104738 NZ_CP029066:c2684550-2684362 [Enterococcus mundtii]
ATGCCCATGACAATCAGAGAAGCAGAAAAGCTACTGAAAGATGCTGGCTTTGTTGAAGTGAAAGGTGGGAAGGGCTCACA
TAGGAAATTCACTAAAAAGGATCATCCTAGACCTGTTATCCTTACTAGCCATTCAAAAGAGTTATCTAGAAGAGTAGAAG
ATTCTGTTCGAAAAGCAGTGGGCATTTAA

Antitoxin

Protein

• Length: 129 a.a.
• Molecular weight: 14293.41 Da
• Isoelectric Point: 4.4851

>AT104738 WP_010734232.1 NZ_CP029066:c2684327-2683941 [Enterococcus mundtii]
MKKVYPAIFEKDPVGYGIYFPDIEGAVTQSKDIIEGLEVASDALGIMLGDLVENNKPLPKPTNINDLSIDSEREFATLIS
VDLNDYLKDVQLDKKTIKIPHWLNVRATNEGINFSKTMSEALVQKLNI

Nucleotide

• Length: 387 bp

>AT104738 NZ_CP029066:c2684327-2683941 [Enterococcus mundtii]
ATGAAAAAAGTTTATCCAGCTATTTTTGAAAAGGATCCTGTTGGATATGGAATTTATTTTCCTGATATCGAAGGAGCAGT
GACACAATCAAAAGATATTATCGAGGGGTTAGAAGTTGCATCGGATGCTTTAGGGATCATGCTCGGTGATTTAGTTGAGA
ATAATAAACCTTTGCCAAAGCCAACTAATATCAATGATCTTTCGATTGATTCTGAGCGTGAATTTGCTACTTTGATTTCT
GTGGATCTAAATGATTACTTAAAAGATGTCCAACTAGATAAAAAGACAATAAAAATTCCTCATTGGTTAAATGTGCGCGC
AACAAATGAAGGGATAAATTTTTCAAAAACAATGTCTGAAGCTTTGGTTCAAAAATTAAATATATGA

Structures

Antitoxin

• AlphaFold DB: V5XTD1