Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3673334..3674008 Replicon chromosome
Accession NZ_CP029065
Organism Mycobacterium tuberculosis strain TBMENG-03

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag DDF83_RS18095 Protein ID WP_003417282.1
Coordinates 3673334..3673762 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag DDF83_RS18100 Protein ID WP_003417286.1
Coordinates 3673766..3674008 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DDF83_RS18070 3669156..3669557 - 402 WP_003417264.1 cytidine deaminase -
DDF83_RS18075 3669698..3670132 + 435 WP_072460198.1 succinate dehydrogenase, cytochrome b556 subunit -
DDF83_RS18080 3670129..3670563 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
DDF83_RS18085 3670692..3672464 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
DDF83_RS18090 3672464..3673255 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
DDF83_RS18095 3673334..3673762 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
DDF83_RS18100 3673766..3674008 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
DDF83_RS18105 3674130..3674744 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
DDF83_RS18110 3674741..3675406 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
DDF83_RS18115 3675407..3675940 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
DDF83_RS18120 3675937..3676320 - 384 WP_050954823.1 4a-hydroxytetrahydrobiopterin dehydratase -
DDF83_RS18125 3676417..3677022 - 606 Protein_3423 cyclic pyranopterin phosphate synthase MoaA -
DDF83_RS18130 3677083..3677193 + 111 Protein_3424 IS110 family transposase -
DDF83_RS18135 3677227..3677832 + 606 WP_003417412.1 carboxymuconolactone decarboxylase family protein -
DDF83_RS18140 3677765..3678703 - 939 WP_003417413.1 sigma-70 family RNA polymerase sigma factor SigJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T104734 WP_003417282.1 NZ_CP029065:c3673762-3673334 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T104734 NZ_CP029065:c3673762-3673334 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT104734 WP_003417286.1 NZ_CP029065:c3674008-3673766 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT104734 NZ_CP029065:c3674008-3673766 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References