104719

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2785617..2786269 Replicon chromosome
Accession NZ_CP029065
Organism Mycobacterium tuberculosis strain TBMENG-03

Toxin (Protein)


Gene name vapC Uniprot ID G0TPX1
Locus tag DDF83_RS13615 Protein ID WP_003412752.1
Coordinates 2785844..2786269 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag DDF83_RS13610 Protein ID WP_003412749.1
Coordinates 2785617..2785838 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DDF83_RS13595 2783857..2784063 - 207 WP_003899347.1 hypothetical protein -
DDF83_RS13600 2784199..2784822 + 624 WP_003900858.1 TIGR00725 family protein -
DDF83_RS13605 2784812..2785564 + 753 WP_003901416.1 hypothetical protein -
DDF83_RS13610 2785617..2785838 + 222 WP_003412749.1 antitoxin Antitoxin
DDF83_RS13615 2785844..2786269 + 426 WP_003412752.1 type II toxin-antitoxin system VapC family toxin Toxin
DDF83_RS13620 2786292..2787473 - 1182 WP_003899351.1 2-oxo acid dehydrogenase subunit E2 -
DDF83_RS13625 2787470..2788516 - 1047 WP_003412757.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
DDF83_RS13630 2788527..2789630 - 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
DDF83_RS13635 2789889..2790710 - 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
DDF83_RS13640 2790707..2791264 - 558 WP_003412768.1 MaoC family dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15392.89 Da        Isoelectric Point: 9.2386

>T104719 WP_003412752.1 NZ_CP029065:2785844-2786269 [Mycobacterium tuberculosis]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

>T104719 NZ_CP029065:2785844-2786269 [Mycobacterium tuberculosis]
GTGGCGCTGCTCGACGTCAACGCATTGGTCGCGCTGGCGTGGGACTCACACATCCACCACGCCCGGATCCGCGAGTGGTT
TACCGCCAACGCCACGCTCGGCTGGGCGACTTGCCCGCTCACCGAAGCCGGCTTCGTGCGGGTGTCGACGAACCCAAAAG
TACTTCCCAGCGCGATCGGGATCGCAGACGCTCGACGGGTCCTCGTGGCACTACGCGCCGTGGGAGGCCACCGCTTCCTG
GCTGACGACGTATCGCTCGTCGATGACGATGTTCCGTTGATCGTCGGTTATCGCCAGGTGACCGACGCCCATCTGCTGAC
ACTCGCCCGCCGGCGCGGCGTCCGCCTGGTCACCTTCGACGCCGGTGTCTTCACCCTCGCCCAACAACGCCCCAAGACGC
CAGTGGAGCTGCTGACCATCCTCTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT104719 WP_003412749.1 NZ_CP029065:2785617-2785838 [Mycobacterium tuberculosis]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp

>AT104719 NZ_CP029065:2785617-2785838 [Mycobacterium tuberculosis]
GTGCGAACGACACTTGACCTTGACGACGATGTGATCGCCGCGGCACGTGAACTTGCCTCCAGCCAGCGCCGCTCGCTCGG
CTCGGTGATTTCCGAACTCGCACGCCGTGGTCTCATGCCCGGACGCGTCGAGGCTGACGACGGGCTGCCGGTGATCCGCG
TTCCAGCCGGGACCCCGCCGATCACACCGGAGATGGTCCGTCGCGCGCTCGATGAGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPX1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References