Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 205122..205669 Replicon plasmid pFORC_081_1
Accession NZ_CP029058
Organism Escherichia coli strain FORC_081

Toxin (Protein)


Gene name parE Uniprot ID W0LWB3
Locus tag FORC81_RS24630 Protein ID WP_000970007.1
Coordinates 205122..205403 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag FORC81_RS24635 Protein ID WP_000079941.1
Coordinates 205400..205669 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC81_RS24600 201749..202351 + 603 WP_000517695.1 hypothetical protein -
FORC81_RS24605 202407..202901 + 495 WP_001459505.1 hypothetical protein -
FORC81_RS25975 202901..203167 + 267 WP_000955263.1 hypothetical protein -
FORC81_RS24620 203644..204117 - 474 WP_001334658.1 hypothetical protein -
FORC81_RS24625 204234..205082 - 849 WP_021265674.1 3'-5' exonuclease -
FORC81_RS24630 205122..205403 - 282 WP_000970007.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FORC81_RS24635 205400..205669 - 270 WP_000079941.1 hypothetical protein Antitoxin
FORC81_RS24640 206027..207172 + 1146 Protein_244 IS91-like element ISVsa3 family transposase -
FORC81_RS25980 207641..208087 + 447 Protein_245 DUF3363 domain-containing protein -
FORC81_RS24650 208304..209518 + 1215 WP_039026029.1 chloramphenicol/florfenicol efflux MFS transporter FloR -
FORC81_RS24655 209546..209767 + 222 Protein_247 LysR family transcriptional regulator -
FORC81_RS24660 209821..210525 - 705 WP_001067855.1 IS6-like element IS26 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sul3 / ant(3'')-Ia / cmlA1 / aadA2 / dfrA12 / qnrS1 / tet(A) / blaTEM-1B / aac(3)-IId / floR - 1..253947 253947
- flank IS/Tn floR - 206036..209518 3482


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10892.63 Da        Isoelectric Point: 9.7617

>T104672 WP_000970007.1 NZ_CP029058:c205403-205122 [Escherichia coli]
MMEIFWTMLASQDRKRIRKYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP

Download         Length: 282 bp

>T104672 NZ_CP029058:c205403-205122 [Escherichia coli]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTAAGTACATTGCGGAGCAGAACCTGAT
GGCCGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTC
GTGTGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTG
TATATCCTGCGCGTGTTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT104672 WP_000079941.1 NZ_CP029058:c205669-205400 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT104672 NZ_CP029058:c205669-205400 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATTCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G1GDN5

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References