Detailed information of TA system TA104657

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 2794082..2794896
• Replicon: chromosome
• Accession: NZ_CP029057
• Organism: Escherichia coli strain FORC_081

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: FORC81_RS13820
• Protein ID: WP_001054376.1
• Coordinates: 2794082..2794339 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: FORC81_RS13825
• Protein ID: WP_001309181.1
• Coordinates: 2794351..2794896 (+)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FORC81_RS13800	2789370..2790476	+	1107	WP_001309184.1	N-acetylneuraminate epimerase	-
FORC81_RS13805	2790541..2791521	+	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
FORC81_RS13810	2792104..2793344	-	1241	Protein_2666	helicase YjhR	-
FORC81_RS13815	2793460..2793705	+	246	Protein_2667	GNAT family N-acetyltransferase	-
FORC81_RS13820	2794082..2794339	+	258	WP_001054376.1	hypothetical protein	Toxin
FORC81_RS13825	2794351..2794896	+	546	WP_001309181.1	N-acetyltransferase	Antitoxin
FORC81_RS13830	2794952..2795698	+	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
FORC81_RS13835	2795867..2796085	+	219	Protein_2671	hypothetical protein	-
FORC81_RS25925	2796123..2796239	+	117	Protein_2672	VOC family protein	-
FORC81_RS13840	2796484..2797605	+	1122	WP_000010829.1	M42 family metallopeptidase	-
FORC81_RS13845	2797602..2797880	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
FORC81_RS13850	2797892..2799205	+	1314	WP_000460843.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimB	2786575..2803120	16545

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T104657 WP_001054376.1 NZ_CP029057:2794082-2794339 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T104657 NZ_CP029057:2794082-2794339 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT104657 WP_001309181.1 NZ_CP029057:2794351-2794896 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT104657 NZ_CP029057:2794351-2794896 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8