Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 955946..956472 | Replicon | chromosome |
| Accession | NZ_CP029057 | ||
| Organism | Escherichia coli strain FORC_081 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | FORC81_RS04670 | Protein ID | WP_000323025.1 |
| Coordinates | 956185..956472 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | FORC81_RS04665 | Protein ID | WP_000534858.1 |
| Coordinates | 955946..956185 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FORC81_RS04630 | 951060..951311 | + | 252 | Protein_892 | DUF977 family protein | - |
| FORC81_RS04635 | 951308..951664 | + | 357 | WP_001310834.1 | class I SAM-dependent methyltransferase | - |
| FORC81_RS25890 | 952275..952562 | + | 288 | Protein_894 | hypothetical protein | - |
| FORC81_RS04650 | 953331..954644 | + | 1314 | WP_000589005.1 | ISNCY family transposase | - |
| FORC81_RS04655 | 955081..955413 | - | 333 | WP_001301033.1 | protein FlxA | - |
| FORC81_RS04660 | 955616..955921 | - | 306 | WP_001326990.1 | hypothetical protein | - |
| FORC81_RS04665 | 955946..956185 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| FORC81_RS04670 | 956185..956472 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| FORC81_RS04675 | 956544..956699 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| FORC81_RS04680 | 956916..957167 | + | 252 | WP_000980994.1 | hypothetical protein | - |
| FORC81_RS04685 | 957234..957512 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| FORC81_RS04690 | 957541..957864 | + | 324 | Protein_903 | antitermination protein | - |
| FORC81_RS04695 | 958142..958231 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| FORC81_RS04700 | 958286..958498 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| FORC81_RS04705 | 958799..959014 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| FORC81_RS04710 | 959768..959983 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| FORC81_RS04715 | 959988..960299 | + | 312 | WP_000189916.1 | YdfR family protein | - |
| FORC81_RS04720 | 960296..960829 | + | 534 | WP_001092971.1 | lysozyme | - |
| FORC81_RS04725 | 960826..961323 | + | 498 | WP_001071769.1 | DUF2514 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 940923..968973 | 28050 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T104649 WP_000323025.1 NZ_CP029057:956185-956472 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T104649 NZ_CP029057:956185-956472 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT104649 WP_000534858.1 NZ_CP029057:955946-956185 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT104649 NZ_CP029057:955946-956185 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|