Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 472938..473591 Replicon chromosome
Accession NZ_CP029005
Organism Acinetobacter pittii strain AbW39

Toxin (Protein)


Gene name cptA Uniprot ID A0A013STE4
Locus tag DDE02_RS02325 Protein ID WP_005078321.1
Coordinates 473202..473591 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A009HHW9
Locus tag DDE02_RS02320 Protein ID WP_002117064.1
Coordinates 472938..473195 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DDE02_RS02300 (DDE02_02315) 468452..469459 + 1008 WP_002116730.1 DNA-directed RNA polymerase subunit alpha -
DDE02_RS02305 (DDE02_02320) 469478..469855 + 378 WP_002049717.1 50S ribosomal protein L17 -
DDE02_RS02310 (DDE02_02325) 470036..471526 + 1491 WP_002116796.1 NAD(P)/FAD-dependent oxidoreductase -
DDE02_RS02315 (DDE02_02330) 471577..472749 - 1173 WP_002116790.1 acyl-CoA dehydrogenase family protein -
DDE02_RS02320 (DDE02_02335) 472938..473195 + 258 WP_002117064.1 succinate dehydrogenase assembly factor 2 Antitoxin
DDE02_RS02325 (DDE02_02340) 473202..473591 + 390 WP_005078321.1 hypothetical protein Toxin
DDE02_RS02330 (DDE02_02345) 474362..475450 + 1089 WP_002116869.1 hypothetical protein -
DDE02_RS02335 (DDE02_02350) 475535..476110 + 576 WP_005078319.1 rhombosortase -
DDE02_RS02340 (DDE02_02355) 476290..478500 + 2211 WP_002116854.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15476.61 Da        Isoelectric Point: 7.9230

>T104585 WP_005078321.1 NZ_CP029005:473202-473591 [Acinetobacter pittii]
MIKELNFELKYSLVSVIFQLFVGLGLAILLYQLLTPIWWLCAVILLFIGFIFFLKQAQISQIEYLDQKLWSVAYFSKKEI
YRAEITKIIDYQLFVVIYLEETPTNIAIVWFDQLPIQQWKRLKVLEKLY

Download         Length: 390 bp

>T104585 NZ_CP029005:473202-473591 [Acinetobacter pittii]
TTGATAAAAGAATTAAATTTTGAGCTGAAATATAGCCTTGTCTCGGTAATATTTCAGCTTTTTGTTGGTTTGGGTTTAGC
AATCCTGCTTTATCAATTATTAACACCGATATGGTGGCTATGTGCTGTCATTCTTCTATTTATTGGTTTTATTTTCTTTC
TAAAGCAAGCCCAAATATCTCAAATTGAATATTTAGATCAAAAATTATGGTCGGTTGCATATTTTTCGAAAAAAGAAATT
TACCGCGCGGAAATTACTAAAATAATTGATTATCAGTTATTTGTAGTTATTTATCTTGAAGAAACTCCTACGAACATAGC
TATTGTTTGGTTCGATCAGCTTCCTATTCAGCAGTGGAAAAGATTAAAAGTTTTAGAAAAGCTCTATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10295.73 Da        Isoelectric Point: 4.4809

>AT104585 WP_002117064.1 NZ_CP029005:472938-473195 [Acinetobacter pittii]
MSDEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVDQEDPDLLDWFMEVSEPPRTELREFIYKLK
QYVHG

Download         Length: 258 bp

>AT104585 NZ_CP029005:472938-473195 [Acinetobacter pittii]
ATGTCTGACGAAATGACCTTGGAAGAACGTAAAGTAATTTATCGAGCACGCCGCGGCTTAAAAGAAATTGACGTCTATTT
TGACCCGTATGTAAAAAACTATTATTTAAAAGCTGATCCAGCAGAAAAAGCATTATTTGCAGAGTTAGTCGATCAAGAAG
ATCCGGATTTATTAGATTGGTTCATGGAAGTTTCTGAACCTCCACGTACTGAGTTACGTGAATTTATTTATAAACTAAAA
CAGTATGTGCATGGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A013STE4

Antitoxin

Source ID Structure
AlphaFold DB A0A009HHW9

References