Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 1677607..1678205 Replicon chromosome
Accession NZ_CP029004
Organism Trueperella pyogenes strain TP-2849

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag DDE06_RS07450 Protein ID WP_108726552.1
Coordinates 1677891..1678205 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag DDE06_RS07445 Protein ID WP_108726551.1
Coordinates 1677607..1677900 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DDE06_RS07415 1673037..1673684 - 648 WP_039661760.1 5-formyltetrahydrofolate cyclo-ligase -
DDE06_RS07420 1673768..1674982 + 1215 WP_108726548.1 molybdopterin molybdotransferase MoeA -
DDE06_RS07425 1675042..1676061 + 1020 WP_039661764.1 hypothetical protein -
DDE06_RS07430 1676058..1676684 + 627 WP_108726549.1 alpha/beta fold hydrolase -
DDE06_RS07440 1677084..1677500 - 417 WP_108726550.1 SRPBCC family protein -
DDE06_RS07445 1677607..1677900 - 294 WP_108726551.1 putative addiction module antidote protein Antitoxin
DDE06_RS07450 1677891..1678205 - 315 WP_108726552.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DDE06_RS07455 1678523..1679383 + 861 WP_126720546.1 siderophore-interacting protein -
DDE06_RS07460 1679711..1680067 + 357 WP_039661774.1 hypothetical protein -
DDE06_RS07465 1680199..1680810 - 612 WP_039663456.1 alpha/beta hydrolase -
DDE06_RS07470 1680954..1681907 - 954 WP_108726554.1 SRPBCC family protein -
DDE06_RS07475 1681904..1682146 - 243 WP_024963636.1 hypothetical protein -
DDE06_RS07480 1682255..1683172 + 918 WP_108726555.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1677084..1690001 12917


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-96)

Antitoxin

Uncharacterized protein HI1420

(4-93)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11875.76 Da        Isoelectric Point: 10.0302

>T104584 WP_108726552.1 NZ_CP029004:c1678205-1677891 [Trueperella pyogenes]
VKIRQTDVYAHWFRELKDVQSKARINIALQRCKIAGEVVGDVKPVGDGVFEMRIHVGPGYRIYYMSRGNQLMLLVIGGDK
STQQRDITKAKQLATEIIREGSWE

Download         Length: 315 bp

>T104584 NZ_CP029004:c1678205-1677891 [Trueperella pyogenes]
GTGAAGATTCGGCAAACCGACGTGTATGCTCACTGGTTTCGCGAGCTAAAAGATGTCCAGAGCAAGGCCCGAATCAATAT
TGCACTTCAGCGTTGCAAAATAGCTGGCGAAGTAGTGGGTGACGTCAAGCCGGTTGGTGATGGCGTTTTTGAGATGCGAA
TTCACGTTGGCCCCGGCTATCGGATTTACTACATGTCAAGAGGGAACCAACTTATGCTACTAGTCATTGGTGGTGATAAG
TCCACCCAGCAGCGTGACATAACCAAAGCTAAACAGCTTGCAACAGAAATTATTAGGGAGGGATCATGGGAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10273.77 Da        Isoelectric Point: 4.8004

>AT104584 WP_108726551.1 NZ_CP029004:c1677900-1677607 [Trueperella pyogenes]
MGVKISTWDASEYLETKEDIAAYLNAALEEGDPALLQVALGDVAKARGVTAIAREAGVGRESLYKSLSENGNPSWRTITK
VLTALGLKIEVKAIALA

Download         Length: 294 bp

>AT104584 NZ_CP029004:c1677900-1677607 [Trueperella pyogenes]
ATGGGAGTAAAAATCAGCACCTGGGATGCCAGCGAATACCTTGAAACCAAGGAAGATATTGCTGCCTACCTGAACGCGGC
ACTCGAAGAGGGCGACCCGGCTCTCCTGCAGGTCGCACTTGGTGATGTCGCCAAAGCGCGTGGTGTGACCGCTATCGCGC
GAGAAGCCGGTGTTGGACGCGAGTCTCTCTACAAGTCGCTTTCCGAAAACGGCAATCCGTCCTGGCGGACCATCACAAAG
GTTCTCACTGCACTCGGGCTGAAGATCGAAGTCAAAGCCATTGCGTTAGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References