Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 1256859..1257457 Replicon chromosome
Accession NZ_CP029001
Organism Trueperella pyogenes strain TP4479

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag DC090_RS05520 Protein ID WP_108726552.1
Coordinates 1257143..1257457 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag DC090_RS05515 Protein ID WP_108726551.1
Coordinates 1256859..1257152 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DC090_RS05485 1252289..1252936 - 648 WP_039661760.1 5-formyltetrahydrofolate cyclo-ligase -
DC090_RS05490 1253020..1254234 + 1215 WP_108726548.1 molybdopterin molybdotransferase MoeA -
DC090_RS05495 1254294..1255313 + 1020 WP_039661764.1 hypothetical protein -
DC090_RS05500 1255310..1255936 + 627 WP_108726549.1 alpha/beta fold hydrolase -
DC090_RS05510 1256336..1256752 - 417 WP_108726550.1 SRPBCC family protein -
DC090_RS05515 1256859..1257152 - 294 WP_108726551.1 putative addiction module antidote protein Antitoxin
DC090_RS05520 1257143..1257457 - 315 WP_108726552.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DC090_RS05525 1257787..1258635 + 849 WP_159081093.1 siderophore-interacting protein -
DC090_RS05530 1258963..1259319 + 357 WP_039661774.1 hypothetical protein -
DC090_RS05535 1259451..1260062 - 612 WP_039663456.1 alpha/beta hydrolase -
DC090_RS05540 1260206..1261159 - 954 WP_108726554.1 SRPBCC family protein -
DC090_RS05545 1261156..1261398 - 243 WP_024963636.1 hypothetical protein -
DC090_RS05550 1261507..1262424 + 918 WP_108726555.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1256336..1269253 12917


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-96)

Antitoxin

Uncharacterized protein HI1420

(4-93)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11875.76 Da        Isoelectric Point: 10.0302

>T104578 WP_108726552.1 NZ_CP029001:c1257457-1257143 [Trueperella pyogenes]
VKIRQTDVYAHWFRELKDVQSKARINIALQRCKIAGEVVGDVKPVGDGVFEMRIHVGPGYRIYYMSRGNQLMLLVIGGDK
STQQRDITKAKQLATEIIREGSWE

Download         Length: 315 bp

>T104578 NZ_CP029001:c1257457-1257143 [Trueperella pyogenes]
GTGAAGATTCGGCAAACCGACGTGTATGCTCACTGGTTTCGCGAGCTAAAAGATGTCCAGAGCAAGGCCCGAATCAATAT
TGCACTTCAGCGTTGCAAAATAGCTGGCGAAGTAGTGGGTGACGTCAAGCCGGTTGGTGATGGCGTTTTTGAGATGCGAA
TTCACGTTGGCCCCGGCTATCGGATTTACTACATGTCAAGAGGGAACCAACTTATGCTACTAGTCATTGGTGGTGATAAG
TCCACCCAGCAGCGTGACATAACCAAAGCTAAACAGCTTGCAACAGAAATTATTAGGGAGGGATCATGGGAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10273.77 Da        Isoelectric Point: 4.8004

>AT104578 WP_108726551.1 NZ_CP029001:c1257152-1256859 [Trueperella pyogenes]
MGVKISTWDASEYLETKEDIAAYLNAALEEGDPALLQVALGDVAKARGVTAIAREAGVGRESLYKSLSENGNPSWRTITK
VLTALGLKIEVKAIALA

Download         Length: 294 bp

>AT104578 NZ_CP029001:c1257152-1256859 [Trueperella pyogenes]
ATGGGAGTAAAAATCAGCACCTGGGATGCCAGCGAATACCTTGAAACCAAGGAAGATATTGCTGCCTACCTGAACGCGGC
ACTCGAAGAGGGCGACCCGGCTCTCCTGCAGGTCGCACTTGGTGATGTCGCCAAAGCGCGTGGTGTGACCGCTATCGCGC
GAGAAGCCGGTGTTGGACGCGAGTCTCTCTACAAGTCGCTTTCCGAAAACGGCAATCCGTCCTGGCGGACCATCACAAAG
GTTCTCACTGCACTCGGGCTGAAGATCGAAGTCAAAGCCATTGCGTTAGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References