104577

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 4396..4976 Replicon plasmid unnamed3
Accession NZ_CP028998
Organism Klebsiella pneumoniae strain AR_0079

Toxin (Protein)


Gene name parE Uniprot ID A0A060VNB1
Locus tag AM458_RS30985 Protein ID WP_001136729.1
Coordinates 4662..4976 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1PRM1
Locus tag AM458_RS30980 Protein ID WP_000093040.1
Coordinates 4396..4674 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM458_RS30950 436..585 - 150 WP_032440454.1 colicin release lysis protein -
AM458_RS30955 670..927 - 258 WP_032440455.1 cloacin -
AM458_RS30960 937..2622 - 1686 WP_032440457.1 cloacin -
AM458_RS30965 2949..3194 + 246 WP_004146442.1 hypothetical protein -
AM458_RS30970 3468..3839 + 372 WP_001237044.1 cell envelope integrity protein TolA -
AM458_RS30975 3836..4054 + 219 WP_002193751.1 TonB family protein -
AM458_RS30980 4396..4674 + 279 WP_000093040.1 CopG family ribbon-helix-helix protein Antitoxin
AM458_RS30985 4662..4976 + 315 WP_001136729.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AM458_RS30990 5140..5568 + 429 WP_001140599.1 hypothetical protein -
AM458_RS30995 5594..5773 + 180 WP_065521055.1 Rop family plasmid primer RNA-binding protein -
AM458_RS31000 5801..6331 - 531 WP_065521056.1 hypothetical protein -
AM458_RS31005 6338..7069 - 732 WP_032448355.1 replication-relaxation family protein -
AM458_RS31010 7069..9030 - 1962 WP_065799589.1 TraM recognition domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..10077 10077


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11847.77 Da        Isoelectric Point: 9.8619

>T104577 WP_001136729.1 NZ_CP028998:4662-4976 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKAGEVIVRAIQQLKTLPDIGRPVPFLPLEYQELVIGFGDSGYVMLYRHDR
EMDRIVIVTVRHQKESGYPGADSL

Download         Length: 315 bp

>T104577 NZ_CP028998:4662-4976 [Klebsiella pneumoniae]
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGAGATTTACAACGCCTCCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGCCGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CATTTCTGCCGCTGGAATATCAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCGGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10709.73 Da        Isoelectric Point: 4.7561

>AT104577 WP_000093040.1 NZ_CP028998:4396-4674 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Download         Length: 279 bp

>AT104577 NZ_CP028998:4396-4674 [Klebsiella pneumoniae]
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AAGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCAGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VNB1

Antitoxin

Source ID Structure
AlphaFold DB A0A2X1PRM1

References