Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-Phd
Location 143748..144433 Replicon plasmid pUSP2
Accession NZ_CP028970
Organism Aminobacter sp. MSH1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DCS14_RS29195 Protein ID WP_108610498.1
Coordinates 144011..144433 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag DCS14_RS29190 Protein ID WP_108610497.1
Coordinates 143748..144014 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DCS14_RS29165 138946..140174 + 1229 WP_108610493.1 IS3 family transposase -
DCS14_RS29170 140212..140304 - 93 Protein_129 Fic family protein -
DCS14_RS29175 140526..141257 - 732 WP_108610494.1 SMC-Scp complex subunit ScpB -
DCS14_RS29180 141263..142294 - 1032 WP_108610495.1 DUF1403 family protein -
DCS14_RS29185 142420..143658 + 1239 WP_108610496.1 site-specific integrase -
DCS14_RS29190 143748..144014 + 267 WP_108610497.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DCS14_RS29195 144011..144433 + 423 WP_108610498.1 type II toxin-antitoxin system VapC family toxin Toxin
DCS14_RS29200 144664..144873 + 210 WP_108610499.1 hypothetical protein -
DCS14_RS29205 144946..146262 - 1317 WP_108610500.1 replication initiation protein RepC -
DCS14_RS29210 146485..147498 - 1014 WP_108610501.1 plasmid partitioning protein RepB -
DCS14_RS29215 147495..148712 - 1218 WP_108610502.1 plasmid partitioning protein RepA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..365485 365485


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-127)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(10-56)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15776.03 Da        Isoelectric Point: 4.8158

>T104537 WP_108610498.1 NZ_CP028970:144011-144433 [Aminobacter sp. MSH1]
MRLLLDTNVLSEVTKQAPDPRVLEWLDQLDEDRSFISVVSIAEIRRGVALMDEGRKREALAEWLAQNLPQRFEQRVLHVD
EPIALAWGDLMAQAKRRGRGLSSMDGLIAATATAKQLTLATRNTKDFEGFAVELFDPWTG

Download         Length: 423 bp

>T104537 NZ_CP028970:144011-144433 [Aminobacter sp. MSH1]
TTGAGGCTCTTGCTCGATACGAATGTCCTGTCTGAGGTTACGAAGCAGGCCCCCGACCCAAGGGTTCTGGAATGGCTGGA
CCAGCTCGATGAAGACCGTTCGTTCATCAGCGTGGTGTCGATTGCCGAAATCCGGCGCGGCGTCGCCCTCATGGACGAGG
GCCGGAAACGCGAGGCTTTGGCCGAATGGCTCGCGCAGAATCTGCCGCAGCGTTTCGAGCAAAGGGTTCTCCATGTTGAC
GAGCCTATTGCTCTGGCCTGGGGCGATCTGATGGCCCAGGCCAAGCGTCGCGGTCGTGGTCTGTCATCAATGGATGGCTT
AATTGCCGCGACAGCGACCGCGAAACAGCTCACCTTGGCCACGCGCAACACCAAGGATTTCGAAGGCTTCGCGGTCGAGC
TCTTCGACCCGTGGACTGGATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9942.33 Da        Isoelectric Point: 10.1733

>AT104537 WP_108610497.1 NZ_CP028970:143748-144014 [Aminobacter sp. MSH1]
MLSVPKDVAKWTVADAKARLSEVMERAQSVPQTITRNGKPSVVVVSAEEWQRKTAHRGTLAEFLMDSPLRSADLDLARQR
DEPRDQRL

Download         Length: 267 bp

>AT104537 NZ_CP028970:143748-144014 [Aminobacter sp. MSH1]
ATGCTATCTGTACCCAAAGACGTTGCCAAATGGACCGTCGCCGACGCCAAAGCCCGGCTGTCGGAGGTTATGGAGCGCGC
GCAGTCCGTACCTCAAACGATCACCCGGAACGGCAAGCCAAGCGTCGTTGTCGTCTCGGCCGAGGAATGGCAGCGCAAGA
CGGCGCACAGGGGCACGCTGGCGGAGTTCCTTATGGACTCACCACTGCGTAGCGCCGATCTCGACCTCGCGCGTCAGCGC
GACGAACCGCGTGATCAGCGGCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References