Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 365109..365643 Replicon plasmid p1
Accession NZ_CP028965
Organism Burkholderia sp. IDO3

Toxin (Protein)


Gene name parE Uniprot ID A0A2A4CB03
Locus tag DCN14_RS37475 Protein ID WP_059889265.1
Coordinates 365109..365408 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A2A4CA47
Locus tag DCN14_RS37480 Protein ID WP_059889264.1
Coordinates 365398..365643 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DCN14_RS37465 360310..362379 - 2070 WP_162826293.1 ATP-binding protein -
DCN14_RS38335 362376..363758 - 1383 WP_143331247.1 type I restriction-modification system subunit M -
DCN14_RS37470 364765..364962 - 198 WP_059889267.1 hypothetical protein -
DCN14_RS37475 365109..365408 - 300 WP_059889265.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DCN14_RS37480 365398..365643 - 246 WP_059889264.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
DCN14_RS38530 366390..367469 + 1080 WP_205212627.1 hypothetical protein -
DCN14_RS38340 367450..367653 - 204 WP_059889261.1 hypothetical protein -
DCN14_RS37490 367650..368663 - 1014 WP_059889259.1 DNA-binding protein -
DCN14_RS37495 368822..369994 + 1173 WP_059896513.1 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..420805 420805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-94)

Antitoxin

Antitoxin ParD

(1-80)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11467.07 Da        Isoelectric Point: 9.8740

>T104529 WP_059889265.1 NZ_CP028965:c365408-365109 [Burkholderia sp. IDO3]
MPVKSRRVRLTPLAETDLEGIWRYTVERWSLEQAERYVGELVAAFERLAGSQGLGRPSRAGAGYRRYPVGSHVVFYRETP
DTLDVIRVLHQRMDVDRHL

Download         Length: 300 bp

>T104529 NZ_CP028965:c365408-365109 [Burkholderia sp. IDO3]
ATGCCGGTTAAGTCGCGTAGGGTACGGCTGACGCCGCTGGCCGAGACCGATCTCGAGGGCATCTGGCGCTACACTGTTGA
ACGCTGGTCGCTCGAACAGGCCGAGCGCTACGTGGGCGAGCTGGTCGCTGCGTTCGAGCGGCTGGCCGGCAGTCAGGGCT
TGGGGCGGCCGAGCCGTGCGGGCGCCGGCTATCGACGCTACCCAGTCGGGTCACACGTGGTGTTCTATCGCGAAACGCCA
GACACCTTGGACGTGATTCGGGTGCTGCATCAACGGATGGATGTCGATCGGCACCTGTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8726.78 Da        Isoelectric Point: 6.4604

>AT104529 WP_059889264.1 NZ_CP028965:c365643-365398 [Burkholderia sp. IDO3]
MSRNTSISLGDHLSQFVDTQVASGRYGSASDVVRAGLRLLETQETELRVLQEALKAGEASGMPEAFDGPTFFARMRAKHA
G

Download         Length: 246 bp

>AT104529 NZ_CP028965:c365643-365398 [Burkholderia sp. IDO3]
ATGTCACGCAATACATCAATCTCGCTGGGGGATCACTTGAGCCAGTTTGTGGACACCCAGGTCGCCTCCGGGCGGTACGG
CTCGGCCAGCGACGTGGTGCGGGCGGGGTTGCGCCTGCTTGAGACGCAGGAAACGGAACTTCGTGTCCTGCAGGAAGCCT
TGAAGGCCGGCGAGGCCTCGGGCATGCCGGAGGCCTTTGATGGACCGACGTTCTTTGCCCGAATGCGGGCCAAGCATGCC
GGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A4CB03

Antitoxin

Source ID Structure
AlphaFold DB A0A2A4CA47

References