Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 174903..175498 Replicon plasmid p1
Accession NZ_CP028965
Organism Burkholderia sp. IDO3

Toxin (Protein)


Gene name chpB Uniprot ID A0A2A4C4A8
Locus tag DCN14_RS36520 Protein ID WP_012218081.1
Coordinates 174903..175253 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID A0A2A4C1X6
Locus tag DCN14_RS36525 Protein ID WP_012218082.1
Coordinates 175247..175498 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DCN14_RS36485 170028..170417 - 390 WP_080512399.1 hypothetical protein -
DCN14_RS36490 170438..170647 - 210 WP_038442273.1 hypothetical protein -
DCN14_RS36495 170665..171024 - 360 WP_012218076.1 hypothetical protein -
DCN14_RS38270 171043..171486 - 444 WP_143331194.1 hypothetical protein -
DCN14_RS36500 171496..171750 - 255 WP_038442290.1 hypothetical protein -
DCN14_RS36505 171806..172750 - 945 WP_012218077.1 hypothetical protein -
DCN14_RS38275 172964..173533 - 570 WP_012218078.1 hypothetical protein -
DCN14_RS38280 173557..173889 - 333 WP_096508413.1 hypothetical protein -
DCN14_RS38285 173974..174135 + 162 WP_155295622.1 hypothetical protein -
DCN14_RS36510 174132..174317 - 186 WP_038442441.1 hypothetical protein -
DCN14_RS36515 174380..174892 - 513 WP_012218080.1 hypothetical protein -
DCN14_RS36520 174903..175253 - 351 WP_012218081.1 type II toxin-antitoxin system ChpB family toxin Toxin
DCN14_RS36525 175247..175498 - 252 WP_012218082.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
DCN14_RS36530 175690..176370 - 681 WP_012218083.1 site-specific integrase -
DCN14_RS36535 176535..176861 + 327 WP_012464905.1 H-NS histone family protein -
DCN14_RS36540 176992..177783 + 792 WP_059888140.1 SOS response-associated peptidase family protein -
DCN14_RS36545 178069..178794 + 726 WP_012211002.1 hypothetical protein -
DCN14_RS36550 178817..179320 - 504 WP_009693532.1 hypothetical protein -
DCN14_RS36555 179347..179622 - 276 WP_009693531.1 DUF4148 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..420805 420805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-115)

Antitoxin

Antitoxin PemI-like

(1-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12420.35 Da        Isoelectric Point: 8.9716

>T104528 WP_012218081.1 NZ_CP028965:c175253-174903 [Burkholderia sp. IDO3]
MVKRVKFDRGDIVRVSLNRTIGREQQGDFRPALVLSPAAFNALGVALVAPITQGGEFARFAGFAVPLSGSGTETQGVALV
NMVRMLDLEARGARTIERAPAEVVEDALARLQSIIE

Download         Length: 351 bp

>T104528 NZ_CP028965:c175253-174903 [Burkholderia sp. IDO3]
ATGGTAAAGCGGGTCAAGTTCGATCGGGGCGACATCGTGCGCGTTAGCCTGAACCGGACCATCGGGCGCGAGCAGCAGGG
CGATTTCCGTCCCGCGCTTGTGCTGTCTCCCGCCGCATTCAATGCCTTGGGGGTGGCGCTCGTCGCGCCGATCACGCAGG
GCGGGGAGTTTGCGCGCTTCGCAGGATTCGCCGTGCCGCTCTCTGGCTCGGGCACCGAGACGCAGGGCGTGGCCTTGGTG
AACATGGTCCGGATGCTCGATCTGGAGGCGCGTGGCGCACGGACGATCGAGCGGGCTCCGGCCGAGGTGGTCGAAGATGC
GCTGGCTCGGCTGCAATCGATAATCGAGTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 8997.39 Da        Isoelectric Point: 6.9770

>AT104528 WP_012218082.1 NZ_CP028965:c175498-175247 [Burkholderia sp. IDO3]
MELKIQKWGNSAAVRLPAVLLEQMHASVGGSLNADVRPDGVLLTPARRKYALDELVAQCDAKAPFPADMAAWGEVRPVGR
EGW

Download         Length: 252 bp

>AT104528 NZ_CP028965:c175498-175247 [Burkholderia sp. IDO3]
ATGGAACTAAAAATTCAGAAATGGGGCAACAGTGCGGCGGTGCGACTCCCCGCCGTGTTGCTCGAGCAGATGCACGCCTC
GGTCGGCGGCTCGCTGAACGCCGACGTGCGTCCGGACGGCGTATTGCTGACCCCCGCGCGCCGCAAGTATGCGCTGGACG
AACTGGTCGCTCAGTGTGATGCGAAAGCGCCTTTCCCGGCGGACATGGCTGCATGGGGTGAGGTCAGGCCGGTAGGGCGT
GAAGGATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A4C4A8

Antitoxin

Source ID Structure
AlphaFold DB A0A2A4C1X6

References