Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 1849509..1850043 Replicon chromosome
Accession NZ_CP028963
Organism Burkholderia sp. IDO3

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag DCN14_RS23180 Protein ID WP_096505338.1
Coordinates 1849744..1850043 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag DCN14_RS23175 Protein ID WP_096505340.1
Coordinates 1849509..1849754 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DCN14_RS23150 1845206..1845472 + 267 WP_096505350.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
DCN14_RS23155 1845469..1845885 + 417 WP_096505348.1 type II toxin-antitoxin system VapC family toxin -
DCN14_RS23160 1845930..1846835 - 906 WP_096505346.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
DCN14_RS23165 1846804..1847874 - 1071 WP_096505344.1 hypothetical protein -
DCN14_RS23170 1848234..1849397 + 1164 WP_096505342.1 amidohydrolase -
DCN14_RS23175 1849509..1849754 + 246 WP_096505340.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
DCN14_RS23180 1849744..1850043 + 300 WP_096505338.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DCN14_RS23185 1850078..1851382 - 1305 WP_096505336.1 cobyrinate a,c-diamide synthase -
DCN14_RS23190 1851386..1851988 - 603 WP_096505334.1 cob(I)yrinic acid a,c-diamide adenosyltransferase -
DCN14_RS23195 1852023..1852400 - 378 WP_096505332.1 cobalamin biosynthesis protein -
DCN14_RS23200 1852397..1853209 - 813 WP_172441907.1 uroporphyrinogen-III C-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(9-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11456.95 Da        Isoelectric Point: 6.3732

>T104527 WP_096505338.1 NZ_CP028963:1849744-1850043 [Burkholderia sp. IDO3]
MAVKGRQLQLTPLAELDLEDIWRYTAEHGSLAQADHYHRDLIATMEALAHGEKVGRACAVREGYFRYAVSSHVVFYRETD
DTLDVIRIPHQRLDIERHL

Download         Length: 300 bp

>T104527 NZ_CP028963:1849744-1850043 [Burkholderia sp. IDO3]
ATGGCGGTTAAGGGTCGGCAGCTTCAACTGACCCCGCTGGCGGAACTCGATCTCGAAGACATCTGGCGCTATACCGCCGA
GCATGGGTCGCTCGCGCAGGCGGACCATTACCACCGCGATCTGATCGCAACGATGGAAGCACTGGCGCACGGAGAAAAGG
TCGGCCGGGCTTGCGCTGTTCGCGAGGGCTATTTCCGGTACGCGGTAAGTTCACACGTCGTTTTCTATCGCGAAACGGAT
GACACGCTCGATGTCATCCGGATTCCGCATCAGCGCCTGGATATCGAGCGGCATCTGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8770.60 Da        Isoelectric Point: 6.2138

>AT104527 WP_096505340.1 NZ_CP028963:1849509-1849754 [Burkholderia sp. IDO3]
MSRNTSVSLDDHFAEFVDSQVQSGRYGSASDVVRAGFRLLESHETQVRALQEALKAGEASGAPRPFDSEAFLTRMRGSHG
G

Download         Length: 246 bp

>AT104527 NZ_CP028963:1849509-1849754 [Burkholderia sp. IDO3]
ATGTCGCGGAACACATCCGTTTCCCTCGATGACCACTTCGCCGAATTCGTCGATTCCCAAGTGCAATCAGGGCGATATGG
CTCTGCGAGCGATGTCGTCCGAGCCGGTTTCCGACTCCTCGAATCCCATGAAACGCAGGTACGTGCGTTGCAAGAAGCGT
TGAAGGCGGGCGAGGCCTCAGGAGCGCCCAGGCCATTCGATAGCGAGGCGTTCCTGACGCGCATGCGGGGATCCCATGGC
GGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References