Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1845206..1845885 Replicon chromosome
Accession NZ_CP028963
Organism Burkholderia sp. IDO3

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag DCN14_RS23155 Protein ID WP_096505348.1
Coordinates 1845469..1845885 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag DCN14_RS23150 Protein ID WP_096505350.1
Coordinates 1845206..1845472 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DCN14_RS23135 1840738..1843005 + 2268 WP_096505354.1 TonB-dependent siderophore receptor -
DCN14_RS23140 1843092..1843931 + 840 WP_096505464.1 N(5)-hydroxyornithine transformylase PvdF -
DCN14_RS23145 1843931..1844953 + 1023 WP_096505352.1 acetyltransferase -
DCN14_RS23150 1845206..1845472 + 267 WP_096505350.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
DCN14_RS23155 1845469..1845885 + 417 WP_096505348.1 type II toxin-antitoxin system VapC family toxin Toxin
DCN14_RS23160 1845930..1846835 - 906 WP_096505346.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
DCN14_RS23165 1846804..1847874 - 1071 WP_096505344.1 hypothetical protein -
DCN14_RS23170 1848234..1849397 + 1164 WP_096505342.1 amidohydrolase -
DCN14_RS23175 1849509..1849754 + 246 WP_096505340.1 type II toxin-antitoxin system ParD family antitoxin -
DCN14_RS23180 1849744..1850043 + 300 WP_096505338.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-130)

Antitoxin

SpoVT-AbrB domain

(7-54)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14480.63 Da        Isoelectric Point: 8.5360

>T104526 WP_096505348.1 NZ_CP028963:1845469-1845885 [Burkholderia sp. IDO3]
VTTLYMLDTNICSFIMRERPPVVLSRLQSCVNAQHRIVVSAITYAEMRFGAVGKKASPKHAALVAAFVARLDGVLSWDTA
AVDATTAIRADLAARGTPIGANDASIAGHAIAAGAVLVTNNSREFSRVAGLSVEDWAA

Download         Length: 417 bp

>T104526 NZ_CP028963:1845469-1845885 [Burkholderia sp. IDO3]
GTGACGACGCTCTATATGCTCGATACGAACATCTGCTCGTTCATCATGCGCGAGCGGCCGCCCGTGGTGTTGTCCCGGCT
GCAGTCGTGCGTCAATGCGCAGCACCGGATCGTTGTGTCGGCGATCACCTATGCCGAAATGCGATTCGGCGCTGTGGGCA
AGAAGGCGTCGCCAAAGCATGCGGCACTCGTGGCGGCCTTCGTCGCACGGCTGGACGGCGTGCTGTCGTGGGATACGGCC
GCGGTCGATGCAACGACCGCGATTCGAGCCGATCTCGCGGCCCGCGGCACGCCGATCGGCGCAAACGATGCGTCGATCGC
CGGCCATGCCATTGCCGCCGGCGCGGTGCTCGTGACGAATAACAGTCGTGAATTCAGTCGCGTCGCGGGGTTGTCCGTCG
AAGACTGGGCAGCTTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9913.08 Da        Isoelectric Point: 4.2917

>AT104526 WP_096505350.1 NZ_CP028963:1845206-1845472 [Burkholderia sp. IDO3]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLLLRPVRPTWLSFASEPLADSDFLVERPAVVETGRFDLSGTDD
DASTEASQ

Download         Length: 267 bp

>AT104526 NZ_CP028963:1845206-1845472 [Burkholderia sp. IDO3]
ATGCGCACCGTTTCCATTTTCAAGAACGCCCGTAACCAGGCAATCCGCATCCCGAAGGACATGGAATTCGAGGGTGTGAC
CGAGCTCGAGATCCGCCGCGAGGGCGATACGCTGCTGCTGCGTCCGGTACGACCGACGTGGCTGTCATTCGCGAGCGAAC
CGCTGGCTGATTCCGATTTCCTCGTCGAGCGCCCGGCCGTCGTCGAAACCGGCCGTTTCGACCTGTCCGGCACCGATGAC
GATGCATCGACGGAGGCGAGCCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References