Detailed information of TA system TA104525

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-vagC/VapC-VagC
• Location: 157444..158081
• Replicon: chromosome
• Accession: NZ_CP028963
• Organism: Burkholderia sp. IDO3

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: DCN14_RS15130
• Protein ID: WP_096506680.1
• Coordinates: 157680..158081 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: -
• Locus tag: DCN14_RS15125
• Protein ID: WP_096506786.1
• Coordinates: 157444..157680 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DCN14_RS15105	152510..153049	+	540	WP_096506684.1	hypothetical protein	-
DCN14_RS15110	153256..154290	+	1035	WP_096506683.1	helix-turn-helix domain-containing protein	-
DCN14_RS15115	154337..155428	-	1092	WP_096506682.1	ADP-heptose--LPS heptosyltransferase	-
DCN14_RS15120	155425..157128	-	1704	WP_096506681.1	thiamine pyrophosphate-binding protein	-
DCN14_RS15125	157444..157680	+	237	WP_096506786.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
DCN14_RS15130	157680..158081	+	402	WP_096506680.1	type II toxin-antitoxin system VapC family toxin	Toxin
DCN14_RS15135	158149..159537	-	1389	WP_096506679.1	L-serine ammonia-lyase	-
DCN14_RS15140	159568..160704	-	1137	WP_096506678.1	alginate lyase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-120)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14978.15 Da
• Isoelectric Point: 5.5933

>T104525 WP_096506680.1 NZ_CP028963:157680-158081 [Burkholderia sp. IDO3]
MPRYMLDTNMCIYLMRHQPEPVARRFAQCYTGDVVMSAITYAELEYGVAVCASPARERHNLAALIDDIPVAPFDVAAAQA
YGPVREAARERKKDHLDKLIAAHAVSLDVVLVTNNERDFVSYPGLRLENWLND

Nucleotide

• Length: 402 bp

>T104525 NZ_CP028963:157680-158081 [Burkholderia sp. IDO3]
ATGCCGCGCTACATGCTCGACACCAACATGTGCATCTATTTGATGAGGCATCAGCCGGAGCCGGTCGCGAGACGATTTGC
GCAGTGTTACACGGGGGACGTCGTGATGTCGGCGATCACGTACGCCGAGCTGGAGTACGGTGTCGCCGTGTGCGCGAGTC
CTGCGCGGGAGCGGCACAATCTTGCCGCGCTGATCGACGATATTCCTGTCGCGCCGTTCGACGTCGCGGCTGCGCAAGCA
TACGGCCCGGTTCGCGAGGCCGCCCGCGAGCGGAAGAAGGATCACCTCGATAAATTGATCGCGGCTCATGCGGTGTCGCT
CGACGTCGTCCTCGTGACCAACAACGAGCGGGATTTCGTCAGCTATCCGGGATTGCGGCTGGAGAATTGGCTGAACGACT
AG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9002.18 Da
• Isoelectric Point: 7.0163

>AT104525 WP_096506786.1 NZ_CP028963:157444-157680 [Burkholderia sp. IDO3]
MHTTKVFRNGNSQAVRIPADLAYERSDIELEIERVGDEIRIRPMRRPLTQALRKFAKFGPDFMAEGRGDQEQAEREGV

Nucleotide

• Length: 237 bp

>AT104525 NZ_CP028963:157444-157680 [Burkholderia sp. IDO3]
ATGCATACCACGAAGGTATTCCGGAACGGCAACTCGCAGGCCGTGCGGATTCCCGCCGACCTCGCCTATGAGCGCAGCGA
TATCGAGCTGGAAATCGAGCGCGTGGGTGACGAAATCCGTATTCGGCCGATGCGGCGGCCTTTGACCCAGGCACTCCGGA
AATTCGCGAAGTTCGGGCCGGACTTCATGGCCGAAGGGCGCGGGGATCAGGAGCAGGCCGAACGCGAGGGTGTGTGA