Detailed information of TA system TA104524

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 2444916..2446164
• Replicon: chromosome
• Accession: NZ_CP028962
• Organism: Burkholderia sp. IDO3

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: DCN14_RS11205
• Protein ID: WP_096501612.1
• Coordinates: 2445583..2446164 (+)
• Length: 194 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: DCN14_RS11200
• Protein ID: WP_096501610.1
• Coordinates: 2444916..2445473 (+)
• Length: 186 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DCN14_RS11175	2440107..2440745	+	639	WP_096501600.1	cysteine hydrolase	-
DCN14_RS11180	2440806..2441537	-	732	WP_096501602.1	ribonuclease T2	-
DCN14_RS11185	2441747..2442325	-	579	WP_096501604.1	hypothetical protein	-
DCN14_RS11190	2442421..2443824	-	1404	WP_096501606.1	hypothetical protein	-
DCN14_RS11195	2444206..2444853	+	648	WP_096501608.1	hypothetical protein	-
DCN14_RS11200	2444916..2445473	+	558	WP_096501610.1	helix-turn-helix domain-containing protein	Antitoxin
DCN14_RS11205	2445583..2446164	+	582	WP_096501612.1	HD domain-containing protein	Toxin
DCN14_RS11210	2446890..2449592	+	2703	WP_143331641.1	type VI secretion system tip protein VgrG	-
DCN14_RS11215	2449596..2450855	+	1260	WP_096501614.1	VRR-NUC domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• 5'-deoxynucleotidase YfbR/HDDC2 (7-147)

Antitoxin

• Cro/C1-type helix-turn-helix domain (12-64)

Sequences

Toxin

Protein

• Length: 194 a.a.
• Molecular weight: 21372.93 Da
• Isoelectric Point: 4.8297

>T104524 WP_096501612.1 NZ_CP028962:2445583-2446164 [Burkholderia sp. IDO3]
MTLDTLHARLDFLRETERLKDVLRSGHTSSGRPESTAEHSWRLCLMALVFADALPGVDTLRLLKLCVVHDLGEALHGDIP
AIEQTAHPDKSTQERDDLLTLTAGLDRAPRDEIVALWDEYEAAASPEARAAKALDKLETILQHNQGSNPPDFDYAFNLGY
GRRYTDAAPLFAAIRSIIDADTRSRIDARNADA

Nucleotide

• Length: 582 bp

>T104524 NZ_CP028962:2445583-2446164 [Burkholderia sp. IDO3]
ATGACCCTCGACACCCTCCACGCGCGGCTCGATTTCCTGCGCGAAACCGAACGCCTGAAAGACGTGCTGCGCAGCGGCCA
CACATCGTCCGGCCGTCCCGAAAGCACGGCCGAGCACAGCTGGCGGCTGTGCCTGATGGCGCTCGTGTTCGCCGATGCAC
TGCCGGGCGTCGACACGCTGAGACTGCTGAAGCTGTGCGTCGTGCACGACCTCGGCGAAGCGCTGCACGGCGACATCCCG
GCGATCGAGCAGACCGCGCATCCGGACAAGAGCACGCAGGAACGCGACGACCTGCTGACGCTGACGGCCGGCCTCGATCG
CGCGCCGCGCGACGAGATCGTCGCGCTGTGGGACGAATACGAGGCCGCCGCGTCGCCGGAAGCGCGTGCCGCAAAGGCGC
TCGACAAGCTCGAGACGATTCTGCAGCACAACCAGGGCAGCAACCCGCCCGACTTCGACTACGCGTTCAATCTCGGCTAC
GGCCGGCGCTACACCGACGCCGCGCCGCTGTTCGCGGCGATCCGCTCGATCATCGATGCGGACACCCGAAGCAGGATCGA
CGCACGCAACGCCGACGCGTAA

Antitoxin

Protein

• Length: 186 a.a.
• Molecular weight: 20201.27 Da
• Isoelectric Point: 10.7101

>AT104524 WP_096501610.1 NZ_CP028962:2444916-2445473 [Burkholderia sp. IDO3]
MTPSPLHTPPLGPQLKRWRALRRVKQSHAAELFGVAQSTISRWEAGIQQMSPDERATAERLLAARLDSAGDQALARLIAG
SAGRMHLVCDLTHRLLACSPSRAAEFSQPLPMLLGTSLWRYASPEIVRMEATLDPLGWHDRAGPPSVEFATGANASRVVP
IRGSTCRWTRMMLSDGSAARLVETL

Nucleotide

• Length: 558 bp

>AT104524 NZ_CP028962:2444916-2445473 [Burkholderia sp. IDO3]
ATGACGCCCTCGCCGCTTCACACCCCGCCGCTCGGCCCGCAGCTGAAGCGCTGGCGCGCGCTGCGCCGCGTGAAGCAGAG
CCATGCGGCCGAACTGTTCGGCGTCGCGCAATCGACGATCTCGCGCTGGGAAGCCGGTATCCAGCAGATGTCGCCCGACG
AGCGCGCGACCGCCGAGCGGCTGCTTGCCGCGCGGCTCGATTCGGCGGGTGACCAGGCGCTCGCGCGGCTCATCGCGGGC
AGCGCTGGGCGCATGCACCTCGTCTGCGATCTCACGCATCGCCTGCTCGCGTGCTCGCCGTCGCGCGCGGCCGAGTTCTC
GCAGCCGCTGCCGATGCTGCTCGGCACGTCGCTGTGGCGCTACGCGTCGCCGGAGATCGTCCGCATGGAGGCCACGCTCG
ATCCGCTCGGCTGGCACGATCGCGCCGGGCCGCCGAGCGTCGAATTCGCGACCGGCGCCAATGCGTCGCGCGTCGTGCCG
ATCCGCGGCAGCACCTGCCGGTGGACGCGGATGATGCTGTCGGACGGTTCGGCCGCGCGGCTCGTCGAAACGCTGTAG