Detailed information of TA system TA104523

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-RelB
• Location: 2356991..2357514
• Replicon: chromosome
• Accession: NZ_CP028962
• Organism: Burkholderia sp. IDO3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: DCN14_RS10745
• Protein ID: WP_096508116.1
• Coordinates: 2357248..2357514 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B1YYI3
• Locus tag: DCN14_RS10740
• Protein ID: WP_012366507.1
• Coordinates: 2356991..2357251 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DCN14_RS10720	2353091..2354479	+	1389	WP_096508113.1	MFS transporter	-
DCN14_RS10725	2354832..2356043	+	1212	WP_096508114.1	winged helix-turn-helix domain-containing protein	-
DCN14_RS10730	2356111..2356329	-	219	WP_006751720.1	DUF1653 domain-containing protein	-
DCN14_RS10735	2356395..2356838	-	444	WP_096508115.1	GNAT family N-acetyltransferase	-
DCN14_RS10740	2356991..2357251	+	261	WP_012366507.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
DCN14_RS10745	2357248..2357514	+	267	WP_096508116.1	Txe/YoeB family addiction module toxin	Toxin
DCN14_RS10750	2357546..2358007	-	462	WP_205212583.1	DUF4087 domain-containing protein	-
DCN14_RS10755	2358119..2358949	+	831	WP_096508118.1	substrate-binding domain-containing protein	-
DCN14_RS10760	2358967..2359590	+	624	WP_096508119.1	HAD hydrolase-like protein	-
DCN14_RS10765	2359979..2360548	+	570	WP_096508120.1	DUF4142 domain-containing protein	-
DCN14_RS10770	2360651..2361250	-	600	WP_096508121.1	GNAT family N-acetyltransferase	-
DCN14_RS10775	2361326..2362240	-	915	WP_096508122.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10438.80 Da
• Isoelectric Point: 9.4575

>T104523 WP_096508116.1 NZ_CP028962:2357248-2357514 [Burkholderia sp. IDO3]
MSVRRVLFTSDAWDDYVYWQGQDRKTLKRINQLIREAQRTPFEGIGKPEPLKANLSGFRSRRIDDTNRLVYEADDLQISI
VSCRYHYA

Nucleotide

• Length: 267 bp

>T104523 NZ_CP028962:2357248-2357514 [Burkholderia sp. IDO3]
ATGAGCGTCCGCCGTGTGCTCTTTACATCCGACGCGTGGGACGACTACGTTTATTGGCAGGGGCAAGACCGCAAGACGCT
CAAGCGCATCAACCAGCTCATTCGCGAAGCCCAACGGACGCCGTTCGAAGGTATCGGCAAACCCGAACCGCTGAAGGCGA
ATCTGTCCGGATTCCGGTCGCGCCGCATCGACGATACGAACCGTCTGGTCTATGAAGCGGACGATCTTCAGATCAGCATC
GTGTCCTGCCGCTATCACTACGCGTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9759.03 Da
• Isoelectric Point: 6.0735

>AT104523 WP_012366507.1 NZ_CP028962:2356991-2357251 [Burkholderia sp. IDO3]
MRTIHFSDARGNLKTVIDQVVDDADVTLITRRDAPNAVIMSQEYYDSLMETVHLLRSPANVAHLERSIAQLRKGKAKEHK
LAEDDE

Nucleotide

• Length: 261 bp

>AT104523 NZ_CP028962:2356991-2357251 [Burkholderia sp. IDO3]
ATGCGCACGATTCACTTTTCGGATGCTCGCGGCAATCTGAAGACGGTCATCGATCAGGTCGTCGACGATGCGGATGTGAC
GCTCATCACGCGTCGCGACGCGCCAAACGCAGTCATCATGTCGCAGGAATACTATGACAGCCTGATGGAGACGGTTCACC
TGCTTCGTTCGCCGGCCAATGTCGCCCACCTCGAACGCTCGATCGCGCAATTGCGCAAGGGCAAGGCGAAAGAGCACAAG
CTCGCGGAGGACGATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A2S9KUE4