Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2286273..2286928 Replicon chromosome
Accession NZ_CP028962
Organism Burkholderia sp. IDO3

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DCN14_RS10435 Protein ID WP_096501450.1
Coordinates 2286273..2286692 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag DCN14_RS10440 Protein ID WP_096501452.1
Coordinates 2286689..2286928 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DCN14_RS10410 2281529..2282323 + 795 WP_096501442.1 AraC family transcriptional regulator -
DCN14_RS10415 2282499..2283455 + 957 WP_096501544.1 DMT family transporter -
DCN14_RS10420 2283797..2284369 + 573 WP_096501444.1 permease -
DCN14_RS10425 2284469..2284603 - 135 WP_096501446.1 entericidin A/B family lipoprotein -
DCN14_RS10430 2284836..2286131 + 1296 WP_096501448.1 aspartate carbamoyltransferase -
DCN14_RS10435 2286273..2286692 - 420 WP_096501450.1 type II toxin-antitoxin system VapC family toxin Toxin
DCN14_RS10440 2286689..2286928 - 240 WP_096501452.1 Arc family DNA-binding protein Antitoxin
DCN14_RS10445 2287249..2289492 + 2244 WP_096501454.1 TonB-dependent siderophore receptor -
DCN14_RS10450 2289496..2290251 + 756 WP_096501456.1 sel1 repeat family protein -
DCN14_RS10455 2290248..2290931 + 684 WP_096501458.1 Fe2+-dependent dioxygenase -
DCN14_RS10460 2291130..2291855 + 726 WP_096501460.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(7-41)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14900.15 Da        Isoelectric Point: 5.1532

>T104522 WP_096501450.1 NZ_CP028962:c2286692-2286273 [Burkholderia sp. IDO3]
MILVDTNVIAEPLRREPSAAVIAWLDAQNVETLFLAAISLAEMRFGVAALPEGRRRDWLQQSIEQRVVPLFRGRILPFDE
AASHAYASLRAQARAMGSAMASADGFIAATAAANGLIVATRDVAPFEAAGLRVIDPWAG

Download         Length: 420 bp

>T104522 NZ_CP028962:c2286692-2286273 [Burkholderia sp. IDO3]
ATGATTCTGGTCGATACCAACGTCATTGCCGAGCCGCTGCGACGCGAGCCGAGTGCGGCCGTGATCGCATGGCTCGACGC
GCAGAACGTCGAGACGCTGTTTCTTGCCGCGATCAGCCTGGCGGAGATGCGGTTCGGTGTGGCCGCGTTGCCGGAAGGGC
GCAGGCGAGACTGGCTGCAGCAAAGCATCGAGCAACGCGTGGTGCCGTTGTTTCGCGGCCGGATCCTGCCGTTCGATGAG
GCGGCCAGTCACGCGTATGCGAGCCTTCGCGCGCAGGCTCGCGCCATGGGCAGCGCGATGGCGTCTGCCGACGGTTTCAT
CGCCGCGACCGCCGCGGCGAACGGCCTGATCGTGGCTACGCGCGACGTCGCGCCGTTCGAAGCGGCGGGCCTGCGCGTGA
TCGATCCGTGGGCTGGCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8693.91 Da        Isoelectric Point: 6.4666

>AT104522 WP_096501452.1 NZ_CP028962:c2286928-2286689 [Burkholderia sp. IDO3]
MPVITVRNLPDEVHRALRIRAAQHGRSTEAEVRDILEQAVRPGGRPRLGTLLVEIGREAGGIDLEIQRGTAPTDPMSFE

Download         Length: 240 bp

>AT104522 NZ_CP028962:c2286928-2286689 [Burkholderia sp. IDO3]
ATGCCCGTGATCACTGTTCGAAATCTGCCCGACGAGGTGCATCGCGCGCTTCGGATTCGTGCCGCGCAACATGGCCGCAG
TACTGAGGCCGAGGTTCGCGACATCCTCGAGCAAGCTGTTCGGCCCGGCGGGCGCCCCAGGCTGGGAACGCTGCTGGTGG
AAATCGGGAGGGAGGCCGGCGGCATCGATTTAGAGATTCAGCGCGGCACAGCGCCAACCGATCCGATGAGCTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References