Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2078982..2080732 Replicon chromosome
Accession NZ_CP028962
Organism Burkholderia sp. IDO3

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag DCN14_RS09530 Protein ID WP_096501134.1
Coordinates 2079836..2080732 (-) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag DCN14_RS09525 Protein ID WP_096501132.1
Coordinates 2078982..2079839 (-) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DCN14_RS09505 2074122..2075612 - 1491 WP_096501124.1 aldehyde dehydrogenase -
DCN14_RS09510 2075693..2076532 - 840 WP_096501126.1 aspartate dehydrogenase -
DCN14_RS09515 2076525..2078195 - 1671 WP_096501128.1 thiamine pyrophosphate-binding protein -
DCN14_RS09520 2078188..2078985 - 798 WP_096501130.1 SDR family oxidoreductase -
DCN14_RS09525 2078982..2079839 - 858 WP_096501132.1 IclR family transcriptional regulator Antitoxin
DCN14_RS09530 2079836..2080732 - 897 WP_096501134.1 alpha/beta fold hydrolase Toxin
DCN14_RS09535 2080751..2081278 - 528 WP_096501136.1 cupin domain-containing protein -
DCN14_RS09540 2081313..2082083 - 771 WP_096501138.1 SDR family oxidoreductase -
DCN14_RS09545 2082076..2083146 - 1071 WP_096501140.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
DCN14_RS09550 2083201..2083512 - 312 WP_096501142.1 hypothetical protein -
DCN14_RS09555 2083514..2083831 - 318 WP_089492513.1 non-heme iron oxygenase ferredoxin subunit -
DCN14_RS09560 2084278..2085357 + 1080 WP_096501144.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-279)

Antitoxin

Transcription regulator IclR, N-terminal

(24-72)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30821.93 Da        Isoelectric Point: 7.3896

>T104521 WP_096501134.1 NZ_CP028962:c2080732-2079836 [Burkholderia sp. IDO3]
MSVIDKRERDRTAAFATLLGQFPEQRCEAGAAGTIGYREAGAQHAGRALPVVLLHGIGSGAASWVRQLDTLGASRRALAW
DAPGYGVSTPVHGASPAAADYAASLNAWLEALGIERCVLVGHSLGAIIAGGLSRVVPARIAGLLLISPAGGYGSAPAETR
DTRRDARLAMLEELGPAGLAEQRSGNMLSGFASDEARAWVRWNMARIVPAGYAQATHLLANADLASDLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAVYSSLIDGFCRQCDRQRGLE

Download         Length: 897 bp

>T104521 NZ_CP028962:c2080732-2079836 [Burkholderia sp. IDO3]
ATGAGTGTCATCGACAAACGTGAACGCGACCGCACCGCGGCGTTCGCCACGCTGCTCGGGCAGTTTCCCGAGCAGCGCTG
CGAGGCCGGCGCGGCGGGCACGATCGGCTACCGTGAGGCCGGCGCGCAGCATGCGGGCCGCGCGCTGCCCGTCGTGCTGC
TGCACGGGATCGGCTCGGGCGCCGCATCGTGGGTGCGCCAGCTCGACACGCTCGGCGCGTCGCGGCGCGCGCTTGCGTGG
GATGCGCCGGGCTACGGCGTATCGACGCCCGTGCACGGCGCATCGCCGGCGGCCGCCGATTACGCGGCGTCGCTGAACGC
GTGGCTCGAGGCACTCGGCATCGAACGCTGCGTGCTGGTCGGGCATTCGCTCGGCGCGATCATCGCGGGCGGCTTGTCCC
GCGTGGTGCCCGCGCGGATCGCCGGCCTGCTGCTGATTTCGCCTGCCGGCGGCTACGGCAGCGCGCCCGCCGAGACGCGC
GACACGCGCCGCGACGCGCGCCTCGCGATGCTCGAGGAGCTCGGCCCGGCCGGGCTCGCCGAGCAGCGCAGCGGCAACAT
GCTGTCCGGTTTCGCGAGCGACGAAGCGCGGGCATGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCCGGCTATGCGC
AGGCCACGCATCTGCTCGCGAACGCCGATCTCGCGTCCGATCTCGCCGGCTTTCGCGGCCGCACGGCGGTGGCGGTCGGC
GCGAACGACGCGATCACGCCGCCGGCTGCCTGCGAGCGCATCGCCGCGGCCGCGCACGTCGGGCTGCAGGTGATTCCGCA
GGCCGGTCATGCCGGTTACGTGGAAGCGCCGGCAGTGTATTCGTCGCTGATCGACGGCTTCTGCCGCCAATGCGATCGTC
AACGGGGGCTGGAATGA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31404.86 Da        Isoelectric Point: 6.6561

>AT104521 WP_096501132.1 NZ_CP028962:c2079839-2078982 [Burkholderia sp. IDO3]
MSEPLQRQDAENAKAEANYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLTELRALYPEGALNRMTSATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNDTQRIVACITVTVP
RPEIDASLIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 858 bp

>AT104521 NZ_CP028962:c2079839-2078982 [Burkholderia sp. IDO3]
ATGAGCGAACCGTTGCAACGACAGGACGCGGAAAACGCGAAGGCCGAGGCCAACTACGTGGTGCCGGGCCTCGAACGCGG
GCTGCGGATCCTCGCCGAATTCTCGCCGCGCGAGCCGGTGCTCGGCGCGCCGGAGCTGTCGAAGCGCCTCGGCATTCCGC
GCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTCCTCGAGCGCGCGGACAAGGATCGCAATTACAAG
CTCGGGATCGCCGTGCTGCGGCTCGGCTTCGAATACCTGAGCTCGCTGGAGCTGACCGATCTCGGCCTGCCGGTGATCGA
GAGCCTGCGCGACGCAACCGGCTTCACGACGCACATCGTGATCCGCGACGGCCGCGACGTGGTGTTCGTCGCGAAGGCGC
AGAGCCAGTCGCCGGTGTTCAGCTCGATTCGCGTGAACGTCGGCACGCGGCTGCCCGCGCATGCGACGACCCACGGCCAC
GTGCTGATGGGCGACCTGTCGCTGACGGAGCTGCGTGCGCTGTATCCGGAAGGCGCGCTGAACCGGATGACGAGCGCGAC
GCCGGAAACGGTCGACGCGCTGTACGAAGTGATCCGCGAGGATGCGCTGCGCGGCTACGGCGTCAGCAATTCGTCGTTCG
AGCGCGGGATCTCGGTGGTCACGGCGCCCGTGCGCAACGACACGCAGAGGATCGTCGCGTGCATCACGGTGACGGTGCCG
CGCCCGGAGATCGACGCGTCGCTGATCGCCGACGGGCTGATCGACAAGGTGCAGCGCGCGGCGGCGGAATTGTCGCGGCG
GCTCAATTACCGCTCGGATGACGAGCACACGTTTCTGAAGGCTTTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References