Detailed information of TA system TA104520

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1785403..1786042
• Replicon: chromosome
• Accession: NZ_CP028962
• Organism: Burkholderia sp. IDO3

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: DCN14_RS08220
• Protein ID: WP_172441857.1
• Coordinates: 1785403..1785819 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A4V8GAU9
• Locus tag: DCN14_RS08225
• Protein ID: WP_014899176.1
• Coordinates: 1785806..1786042 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DCN14_RS08195	1780561..1781673	-	1113	WP_096499577.1	nitronate monooxygenase	-
DCN14_RS08200	1781670..1782587	-	918	WP_096499579.1	enoyl-CoA hydratase	-
DCN14_RS08205	1782596..1783393	-	798	WP_096499581.1	ketoacid CoA transferase	-
DCN14_RS08210	1783404..1784297	-	894	WP_096499583.1	CoA transferase subunit A	-
DCN14_RS08215	1784307..1785203	-	897	WP_096499585.1	VOC family protein	-
DCN14_RS08220	1785403..1785819	-	417	WP_172441857.1	type II toxin-antitoxin system VapC family toxin	Toxin
DCN14_RS08225	1785806..1786042	-	237	WP_014899176.1	DNA-binding protein	Antitoxin
DCN14_RS08230	1786392..1787045	-	654	WP_096499589.1	hypothetical protein	-
DCN14_RS08235	1787901..1788224	-	324	WP_096499591.1	DUF1634 domain-containing protein	-
DCN14_RS08240	1788221..1789072	-	852	WP_096499593.1	sulfite exporter TauE/SafE family protein	-
DCN14_RS08245	1789086..1789829	-	744	WP_096499595.1	GntR family transcriptional regulator	-
DCN14_RS08250	1789892..1790665	-	774	WP_096499597.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-130)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15421.60 Da
• Isoelectric Point: 6.8816

>T104520 WP_172441857.1 NZ_CP028962:c1785819-1785403 [Burkholderia sp. IDO3]
VFLIDTNVISEIRKGKRTNRGVRAFFRQAEADASPLYLSVVTVAELRRGVDLIRHRGDHQQASALEAWMAMILSGYASNI
LPVDIETSQTWGHLRVPDPTHELDKLIAATALINDLTVVTRNVDDFARTGVRLLNPFD

Nucleotide

• Length: 417 bp

>T104520 NZ_CP028962:c1785819-1785403 [Burkholderia sp. IDO3]
GTGTTTTTGATTGATACGAACGTCATCAGCGAGATCAGAAAGGGCAAGCGAACCAACCGCGGCGTGCGCGCATTCTTCCG
GCAGGCCGAGGCCGACGCGAGCCCGCTTTACCTGTCGGTCGTCACGGTGGCCGAACTTCGGCGCGGCGTCGATCTGATCC
GTCATCGCGGCGATCACCAGCAGGCGTCGGCGCTCGAGGCCTGGATGGCGATGATCCTGTCCGGCTATGCGTCGAACATC
CTGCCGGTCGATATCGAGACCAGCCAGACGTGGGGCCATCTGCGCGTGCCCGATCCGACCCACGAACTCGACAAACTGAT
CGCGGCCACCGCGCTGATCAACGATCTCACGGTCGTCACGCGTAATGTCGACGATTTCGCCCGCACCGGCGTCCGGCTGC
TGAACCCTTTCGACTGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8668.70 Da
• Isoelectric Point: 5.0628

>AT104520 WP_014899176.1 NZ_CP028962:c1786042-1785806 [Burkholderia sp. IDO3]
MANLLVRNVDDSIVQSLREQAAANGRSAEAEHRAILADALGRPKRRTFAQVLMSMPDVGEDADFQRVQDSGEVRRVFD

Nucleotide

• Length: 237 bp

>AT104520 NZ_CP028962:c1786042-1785806 [Burkholderia sp. IDO3]
ATGGCAAATCTTCTGGTGCGTAACGTGGATGACAGTATCGTTCAGAGCCTGCGCGAGCAGGCTGCGGCCAACGGCAGGAG
CGCCGAGGCCGAACATCGGGCCATCCTGGCCGATGCGCTCGGCCGGCCGAAGCGACGGACATTCGCGCAGGTGCTGATGA
GCATGCCGGACGTCGGCGAAGACGCGGATTTCCAACGTGTTCAGGATTCCGGCGAGGTCAGGCGTGTTTTTGATTGA

Structures

Antitoxin

• AlphaFold DB: A0A4V8GAU9