Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1211086..1211732 Replicon chromosome
Accession NZ_CP028962
Organism Burkholderia sp. IDO3

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DCN14_RS05635 Protein ID WP_096499254.1
Coordinates 1211325..1211732 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag DCN14_RS05630 Protein ID WP_096499256.1
Coordinates 1211086..1211328 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DCN14_RS05615 1207075..1208481 + 1407 WP_096499262.1 aspartate ammonia-lyase -
DCN14_RS05620 1208585..1210078 + 1494 WP_096499260.1 amino acid permease -
DCN14_RS05625 1210131..1210820 - 690 WP_096499258.1 phospholipase -
DCN14_RS05630 1211086..1211328 + 243 WP_096499256.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
DCN14_RS05635 1211325..1211732 + 408 WP_096499254.1 type II toxin-antitoxin system VapC family toxin Toxin
DCN14_RS05640 1211829..1213316 - 1488 WP_096499251.1 aldehyde dehydrogenase -
DCN14_RS05645 1213345..1213923 - 579 WP_096499249.1 thioesterase family protein -
DCN14_RS05650 1214186..1215316 + 1131 WP_096499353.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-117)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14731.74 Da        Isoelectric Point: 5.9809

>T104518 WP_096499254.1 NZ_CP028962:1211325-1211732 [Burkholderia sp. IDO3]
MKFLLDTNAVIAILKGDPAVLARLHRHQPADFGMPAIVAHELYYGAYKSQRVEANLARVAGLQFEVVSFDAEDAQHAGEI
RAQLTAAGTPIGPYDALIAGQARARRLVLVTHNTREFEGVTALEVEDWLAGPREN

Download         Length: 408 bp

>T104518 NZ_CP028962:1211325-1211732 [Burkholderia sp. IDO3]
ATGAAGTTTCTGCTGGATACCAATGCGGTGATCGCCATTCTAAAAGGCGACCCAGCCGTGCTGGCCCGATTGCATAGGCA
TCAACCCGCGGATTTCGGAATGCCCGCGATCGTCGCGCATGAACTCTATTACGGTGCGTACAAAAGTCAGCGAGTGGAAG
CGAATCTCGCACGCGTCGCGGGGCTCCAGTTCGAGGTCGTATCGTTTGACGCGGAAGATGCTCAACATGCCGGTGAAATT
CGTGCGCAACTGACTGCGGCGGGAACACCGATCGGTCCATATGATGCGTTGATCGCGGGGCAGGCGCGAGCGCGGAGACT
TGTACTCGTTACGCATAACACGCGCGAATTCGAGGGGGTCACTGCGCTGGAGGTCGAGGATTGGCTCGCAGGGCCGCGCG
AAAACTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8930.07 Da        Isoelectric Point: 4.7628

>AT104518 WP_096499256.1 NZ_CP028962:1211086-1211328 [Burkholderia sp. IDO3]
METAKIFRHGGSQAVRLPKDFRFDTTEVRIRRHGASVILEPVPQDWAWLTPLIGPVDADFEAAATTEPAAQERPGLDVFE

Download         Length: 243 bp

>AT104518 NZ_CP028962:1211086-1211328 [Burkholderia sp. IDO3]
ATGGAGACTGCCAAGATTTTCAGGCATGGCGGATCGCAGGCCGTCCGTTTGCCGAAGGATTTCCGCTTCGACACGACGGA
GGTACGGATTCGTCGGCACGGCGCGTCTGTCATTCTCGAACCCGTGCCGCAAGACTGGGCATGGCTGACGCCGTTGATCG
GCCCGGTTGACGCAGATTTCGAGGCCGCTGCGACGACCGAACCCGCCGCTCAGGAGCGTCCGGGGCTGGACGTCTTCGAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References