Detailed information of TA system TA104506

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 2301511..2302137
• Replicon: chromosome
• Accession: NZ_CP028956
• Organism: Morganella morganii strain AR_0133

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: A0A0A2RCL2
• Locus tag: AM380_RS10845
• Protein ID: WP_024474604.1
• Coordinates: 2301511..2301714 (-)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: AM380_RS10850
• Protein ID: WP_108656294.1
• Coordinates: 2301778..2302137 (-)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM380_RS10820	2298067..2298405	+	339	WP_072869510.1	P-II family nitrogen regulator	-
AM380_RS10825	2298425..2299714	+	1290	WP_108657589.1	ammonium transporter AmtB	-
AM380_RS10830	2299775..2300638	-	864	WP_108656292.1	acyl-CoA thioesterase II	-
AM380_RS10845	2301511..2301714	-	204	WP_024474604.1	hemolysin expression modulator Hha	Toxin
AM380_RS10850	2301778..2302137	-	360	WP_108656294.1	Hha toxicity modulator TomB	Antitoxin
AM380_RS10855	2302700..2305876	-	3177	WP_108656295.1	efflux RND transporter permease subunit	-
AM380_RS10860	2305891..2307084	-	1194	WP_108656296.1	efflux RND transporter periplasmic adaptor subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (8-64)

Antitoxin

• Biofilm formation regulator YbaJ (1-114)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 8073.39 Da
• Isoelectric Point: 6.9770

>T104506 WP_024474604.1 NZ_CP028956:c2301714-2301511 [Morganella morganii]
MTKLDYLMRLRKCTSIETLERVIEKNKYELTDDELEVFYSAADHRLAELTMNKLYDKIPASVWKFVR

Nucleotide

• Length: 204 bp

>T104506 NZ_CP028956:c2301714-2301511 [Morganella morganii]
ATGACTAAACTGGACTATCTCATGCGCTTACGTAAGTGCACTTCTATTGAAACACTGGAACGTGTCATTGAGAAGAACAA
ATATGAACTGACTGATGATGAGCTGGAGGTTTTTTATTCAGCAGCCGATCATCGTCTGGCCGAATTAACCATGAATAAAC
TGTATGACAAAATCCCGGCATCTGTCTGGAAATTTGTCCGTTAA

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 13883.59 Da
• Isoelectric Point: 4.2870

>AT104506 WP_108656294.1 NZ_CP028956:c2302137-2301778 [Morganella morganii]
MDEYSPRNYDIAVLKYLCDELCREGTQTLIRSNNYWVNDLASDSNLKLNELLGYIADVTWSFKIKHTQNKDLISFVDEYI
DETYALFGQMEVSFNDVEEWKKMASLVSNMLTSEGHLVH

Nucleotide

• Length: 360 bp

>AT104506 NZ_CP028956:c2302137-2301778 [Morganella morganii]
ATGGACGAGTATTCTCCACGAAATTACGATATTGCGGTACTGAAGTATCTGTGTGATGAACTTTGCCGTGAAGGCACACA
AACCCTCATCAGAAGCAATAATTATTGGGTTAATGATTTAGCCTCAGATTCAAACTTAAAACTTAACGAATTATTAGGTT
ACATTGCTGACGTGACCTGGAGTTTTAAGATAAAACATACACAAAATAAGGATCTCATCTCATTTGTCGATGAATACATC
GATGAAACTTACGCGCTGTTTGGTCAGATGGAAGTTTCGTTTAATGACGTTGAGGAATGGAAGAAGATGGCATCACTGGT
AAGCAACATGCTGACCAGCGAGGGACATCTTGTCCACTAA

Structures

Toxin

• AlphaFold DB: A0A0A2RCL2