Detailed information of TA system TA104505

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1710227..1711818
• Replicon: chromosome
• Accession: NZ_CP028956
• Organism: Morganella morganii strain AR_0133

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: AM380_RS08190
• Protein ID: WP_108655985.1
• Coordinates: 1710517..1711818 (+)
• Length: 434 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A2S1BBW2
• Locus tag: AM380_RS08185
• Protein ID: WP_054424967.1
• Coordinates: 1710227..1710514 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM380_RS08165	1705751..1707784	-	2034	WP_108655982.1	AAA family ATPase	-
AM380_RS08170	1707777..1708307	-	531	WP_080998367.1	ash family protein	-
AM380_RS08175	1708304..1708504	-	201	WP_199914326.1	AlpA family transcriptional regulator	-
AM380_RS08180	1708507..1709385	-	879	WP_108655984.1	integrase domain-containing protein	-
AM380_RS08185	1710227..1710514	+	288	WP_054424967.1	helix-turn-helix domain-containing protein	Antitoxin
AM380_RS08190	1710517..1711818	+	1302	WP_108655985.1	type II toxin-antitoxin system HipA family toxin	Toxin
AM380_RS08195	1712115..1712804	+	690	WP_108655986.1	sce7726 family protein	-
AM380_RS08200	1712854..1713966	-	1113	WP_108655987.1	beta family protein	-
AM380_RS08205	1713979..1714476	-	498	WP_108655988.1	ImmA/IrrE family metallo-endopeptidase	-
AM380_RS08210	1714476..1715102	-	627	WP_108655989.1	hypothetical protein	-
AM380_RS21405	1716273..1716605	+	333	WP_108655990.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1696871..1727768	30897

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (8-108)

Antitoxin

• Cro/C1-type helix-turn-helix domain (20-68)

Sequences

Toxin

Protein

• Length: 434 a.a.
• Molecular weight: 49375.16 Da
• Isoelectric Point: 5.2289

>T104505 WP_108655985.1 NZ_CP028956:1710517-1711818 [Morganella morganii]
MSRTQQRLAIWMNGIRVGFWEKIRGEDRLHYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEDIRRRL
AMRYRAESLEPFDLLAELGRDCVGAIQLLHPDDEPTDLFSVNYRPLSEADIAAILRNTTTSIPGRHSDDEELRLSIAGAQ
EKTALLWNDGQWCLPEGNTPTTHIFKLPLGLVGNMKADMSTSVENEWLCSLILEHYGIPVAKTQIAQFEDQKVLIVDRFD
RRWSTDRQWIVRLPQEDMCQALGVSPLRKYQADGGPGITDIMGILSHSEQAEQDRETFFKAQIIFWLMAATDGHAKNFSI
SMEPQNRYRLTPLYDVLSAWPLIGNGNNQIAWQKCKLAMAVRGSSNYYLISKIQRRHWIRHGESVGFEKQQVEAMLDDII
DRTPEVIERVTALLPEGFPVGVAEGVFEGVKGK

Nucleotide

• Length: 1302 bp

>T104505 NZ_CP028956:1710517-1711818 [Morganella morganii]
ATGAGCCGGACACAACAACGTTTAGCAATATGGATGAACGGAATCCGTGTCGGATTCTGGGAAAAGATCAGAGGGGAAGA
CCGGCTGCACTATCTCCCGGAGTGGGTTGCTGATGAACAAGGCAGACCGCTGTCTCTTTCATTACCGTTCACGCCGGGTA
ATCAGGTCTGGCGCGGAAATGTTGTGCGTGATTACTTTGATAATTTATTGCCGGATAGTGAGGATATCCGCAGGCGTCTG
GCGATGCGCTACAGAGCGGAAAGTCTGGAACCTTTTGACCTGCTGGCCGAACTGGGAAGAGATTGTGTCGGGGCAATTCA
ATTGCTGCATCCGGATGATGAACCGACAGACTTATTTTCTGTCAATTACCGGCCGCTTTCGGAAGCGGACATTGCAGCGA
TACTGCGTAATACCACAACGTCAATTCCCGGTCGTCATAGCGATGATGAAGAGTTGCGGTTATCTATCGCAGGTGCGCAG
GAAAAAACGGCTTTACTGTGGAATGATGGACAATGGTGTTTACCGGAAGGTAATACACCGACGACTCATATCTTCAAATT
ACCGCTTGGCTTAGTCGGCAATATGAAGGCGGATATGAGCACATCAGTTGAAAATGAATGGCTGTGTTCGCTGATCCTTG
AACACTATGGTATTCCTGTCGCAAAAACACAGATTGCGCAGTTTGAAGACCAGAAAGTCTTGATTGTGGATCGCTTTGAC
CGGCGCTGGTCAACTGACAGACAGTGGATTGTCCGTTTGCCGCAGGAGGACATGTGTCAGGCACTGGGCGTTTCACCGCT
GCGGAAATATCAGGCTGATGGTGGCCCAGGTATCACGGATATCATGGGAATACTGAGTCATTCCGAGCAGGCGGAGCAGG
ATAGAGAGACCTTTTTTAAAGCACAGATTATTTTCTGGCTGATGGCCGCCACAGACGGGCATGCCAAAAACTTCAGTATT
TCCATGGAACCTCAAAACCGTTACCGTCTGACGCCTTTGTATGATGTTCTATCTGCATGGCCGCTGATTGGTAATGGTAA
TAACCAGATTGCCTGGCAGAAATGCAAATTAGCAATGGCTGTCCGGGGAAGTAGTAACTATTACCTGATTAGTAAAATTC
AGCGCCGTCATTGGATCAGACATGGCGAGTCAGTTGGATTTGAAAAACAACAAGTTGAAGCAATGCTGGATGACATTATC
GACCGGACACCAGAAGTGATTGAGCGTGTGACTGCGTTGTTGCCGGAGGGGTTTCCGGTTGGAGTTGCGGAGGGGGTTTT
TGAGGGGGTGAAAGGTAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10583.19 Da
• Isoelectric Point: 10.0937

>AT104505 WP_054424967.1 NZ_CP028956:1710227-1710514 [Morganella morganii]
MNTAYPLKTLNQLRPLLVGFRKANGMTQKDVSEKLGVTQQTYARLEANPASASIERLFKVFTVLGVEMVLSAGQFSVIQE
SAEIPDNSPARREKW

Nucleotide

• Length: 288 bp

>AT104505 NZ_CP028956:1710227-1710514 [Morganella morganii]
ATGAACACTGCTTATCCGCTTAAAACACTCAATCAGTTGCGTCCGTTGCTGGTCGGCTTTCGTAAGGCTAACGGAATGAC
GCAAAAAGACGTCTCAGAGAAACTAGGCGTTACGCAGCAGACCTATGCCCGCCTGGAAGCTAATCCGGCCAGTGCCAGTA
TTGAACGACTATTCAAAGTATTCACGGTGTTGGGTGTCGAAATGGTGCTTTCTGCCGGGCAATTCTCAGTGATTCAGGAA
TCTGCGGAAATACCGGATAACTCTCCGGCCAGACGGGAGAAATGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A2S1BBW2