Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4799968..4800625 Replicon chromosome
Accession NZ_CP028953
Organism Klebsiella pneumoniae strain AR_0141

Toxin (Protein)


Gene name cptA Uniprot ID A0A2N4VX63
Locus tag AM388_RS24315 Protein ID WP_023290968.1
Coordinates 4800215..4800625 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag AM388_RS24310 Protein ID WP_002916312.1
Coordinates 4799968..4800234 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM388_RS24285 4795118..4796551 - 1434 WP_023290972.1 6-phospho-beta-glucosidase BglA -
AM388_RS24290 4796670..4797398 - 729 WP_032428985.1 MurR/RpiR family transcriptional regulator -
AM388_RS24295 4797449..4797760 + 312 WP_023290970.1 N(4)-acetylcytidine aminohydrolase -
AM388_RS24300 4797924..4798583 + 660 WP_008806429.1 hemolysin III family protein -
AM388_RS24305 4798739..4799722 - 984 WP_023290969.1 tRNA-modifying protein YgfZ -
AM388_RS24310 4799968..4800234 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
AM388_RS24315 4800215..4800625 + 411 WP_023290968.1 protein YgfX Toxin
AM388_RS24320 4800632..4801153 - 522 WP_004205324.1 flavodoxin FldB -
AM388_RS24325 4801254..4802150 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
AM388_RS24330 4802173..4802886 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
AM388_RS24335 4802892..4804625 + 1734 WP_023290967.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16075.89 Da        Isoelectric Point: 11.4778

>T104502 WP_023290968.1 NZ_CP028953:4800215-4800625 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDPGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T104502 NZ_CP028953:4800215-4800625 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTCCACGGCGTTGTGGCGGC
GCTGGTGCTGCTGGTTCCCTGGCCGTTAAGCTACACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTTGACTGTG
TGCGCAGCCAGCGACGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGGCTACGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTCATCAACAGCGGTATGTTGCTGCGTTTGCGCCATGTCGATACCCGACGCGG
TCAGCATCTGTGGCTGGCGGCGGACAGCATGGATCCCGGAGAGTGGCGGGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT104502 WP_002916312.1 NZ_CP028953:4799968-4800234 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT104502 NZ_CP028953:4799968-4800234 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N4VX63

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References