Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3444763..3445279 Replicon chromosome
Accession NZ_CP028953
Organism Klebsiella pneumoniae strain AR_0141

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag AM388_RS17365 Protein ID WP_009309309.1
Coordinates 3444763..3445047 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag AM388_RS17370 Protein ID WP_002886901.1
Coordinates 3445037..3445279 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM388_RS17345 3440247..3440555 - 309 WP_020079792.1 PTS sugar transporter subunit IIB -
AM388_RS29185 3440640..3440813 + 174 WP_032412860.1 hypothetical protein -
AM388_RS17350 3440816..3441559 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
AM388_RS17355 3441916..3444054 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
AM388_RS17360 3444295..3444759 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
AM388_RS17365 3444763..3445047 - 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AM388_RS17370 3445037..3445279 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AM388_RS17375 3445357..3447267 - 1911 WP_023280782.1 BglG family transcription antiterminator -
AM388_RS17380 3447290..3448444 - 1155 WP_023280781.1 lactonase family protein -
AM388_RS17385 3448511..3449251 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T104497 WP_009309309.1 NZ_CP028953:c3445047-3444763 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T104497 NZ_CP028953:c3445047-3444763 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCTGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCTGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT104497 WP_002886901.1 NZ_CP028953:c3445279-3445037 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT104497 NZ_CP028953:c3445279-3445037 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References