Detailed information of TA system TA104474

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 921356..921872
• Replicon: chromosome
• Accession: NZ_CP028950
• Organism: Enterobacter cloacae complex sp. FDA-CDC-AR_0164

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: AM410_RS04500
• Protein ID: WP_108647580.1
• Coordinates: 921356..921640 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: AM410_RS04505
• Protein ID: WP_108647582.1
• Coordinates: 921630..921872 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM410_RS04480	917717..918289	+	573	WP_108647578.1	PTS sugar transporter subunit IIA	-
AM410_RS04490	918657..920795	+	2139	WP_020885401.1	anaerobic ribonucleoside-triphosphate reductase	-
AM410_RS04495	920888..921352	+	465	WP_059306428.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
AM410_RS04500	921356..921640	-	285	WP_108647580.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AM410_RS04505	921630..921872	-	243	WP_108647582.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
AM410_RS04510	921950..923860	-	1911	WP_014168384.1	BglG family transcription antiterminator	-
AM410_RS04515	923880..925016	-	1137	WP_108647584.1	lactonase family protein	-
AM410_RS04520	925135..925875	-	741	WP_059306432.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10952.75 Da
• Isoelectric Point: 10.3193

>T104474 WP_108647580.1 NZ_CP028950:c921640-921356 [Enterobacter cloacae complex sp. FDA-CDC-AR_0164]
MSYELVFDPRAFKEWTRLGDTVKNQFKKKLANVLVNPRVESARLHGLPDCDKIKLRSQGYRLVYQVQDNVVTVCVIAIGK
REKSAFYHDVNKRL

Nucleotide

• Length: 285 bp

>T104474 NZ_CP028950:c921640-921356 [Enterobacter cloacae complex sp. FDA-CDC-AR_0164]
ATGAGTTATGAACTCGTATTTGATCCGAGGGCGTTCAAGGAGTGGACCAGGCTGGGTGATACCGTAAAAAATCAGTTTAA
GAAGAAGCTTGCGAACGTGTTGGTGAACCCCAGGGTTGAATCGGCTCGCCTGCATGGCCTGCCTGATTGCGACAAGATAA
AACTCAGATCCCAGGGTTATCGTTTGGTCTATCAGGTTCAGGACAACGTTGTGACGGTATGTGTTATTGCTATCGGTAAG
AGAGAGAAATCAGCCTTTTATCATGACGTAAACAAACGGCTTTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9099.52 Da
• Isoelectric Point: 5.1231

>AT104474 WP_108647582.1 NZ_CP028950:c921872-921630 [Enterobacter cloacae complex sp. FDA-CDC-AR_0164]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTVSDSEDELIQTVRERLANPQKGIKVRLDEL

Nucleotide

• Length: 243 bp

>AT104474 NZ_CP028950:c921872-921630 [Enterobacter cloacae complex sp. FDA-CDC-AR_0164]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAACGAGGCTTATGCCGTGCTTGAAAAACTCAATATCACGCC
AACGGAAGCCGTTCGGTTACTGTTTCAGTACGTTGCGGAGACGGGGCGTATGCCGGTGAAAACGGTCACTGTTAGCGACA
GTGAAGATGAACTCATACAGACAGTCCGGGAGCGGCTGGCTAATCCGCAAAAAGGAATTAAGGTTAGGCTGGATGAGTTA
TGA