Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 354560..355180 Replicon chromosome
Accession NZ_CP028950
Organism Enterobacter cloacae complex sp. FDA-CDC-AR_0164

Toxin (Protein)


Gene name Hha Uniprot ID G8LPY2
Locus tag AM410_RS01775 Protein ID WP_014168902.1
Coordinates 354962..355180 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID W0BRV6
Locus tag AM410_RS01770 Protein ID WP_020885187.1
Coordinates 354560..354934 (+) Length 125 a.a.

Genomic Context

AM410_RS01760AM410_RS01765AM410_RS01770AM410_RS01775AM410_RS01780AM410_RS01785AM410_RS01795AM410_RS01790AM410_RS01800AM410_RS01805
Location: 349686..350879 (1194 bp)
Type: Others
Protein ID: WP_020885186.1
Location: 350902..354048 (3147 bp)
Type: Others
Protein ID: WP_014168904.1
Location: 354560..354934 (375 bp)
Type: Antitoxin
Protein ID: WP_020885187.1
Location: 354962..355180 (219 bp)
Type: Toxin
Protein ID: WP_014168902.1
Location: 355390..355941 (552 bp)
Type: Others
Protein ID: WP_020885188.1
Location: 356059..356526 (468 bp)
Type: Others
Protein ID: WP_032677533.1
Location: 358059..358769 (711 bp)
Type: Others
Protein ID: WP_073395633.1
Location: 356498..357958 (1461 bp)
Type: Others
Protein ID: WP_108647463.1
Location: 358766..358906 (141 bp)
Type: Others
Protein ID: WP_003859006.1
Location: 358909..359169 (261 bp)
Type: Others
Protein ID: WP_010428154.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AM410_RS01760349686..350879+1194WP_020885186.1multidrug efflux RND transporter periplasmic adaptor subunit AcrA-
AM410_RS01765350902..354048+3147WP_014168904.1multidrug efflux RND transporter permease subunit-
AM410_RS01770354560..354934+375WP_020885187.1Hha toxicity modulator TomBAntitoxin
AM410_RS01775354962..355180+219WP_014168902.1hemolysin expression modulator HhaToxin
AM410_RS01780355390..355941+552WP_020885188.1maltose O-acetyltransferase-
AM410_RS01785356059..356526+468WP_032677533.1membrane protein-
AM410_RS01790356498..357958-1461WP_108647463.1PLP-dependent aminotransferase family protein-
AM410_RS01795358059..358769+711WP_073395633.1GNAT family N-acetyltransferase-
AM410_RS01800358766..358906-141WP_003859006.1type B 50S ribosomal protein L36-
AM410_RS01805358909..359169-261WP_010428154.1type B 50S ribosomal protein L31-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8654.04 Da        Isoelectric Point: 8.9107

>T104472 WP_014168902.1 NZ_CP028950:354962-355180 [Enterobacter cloacae complex sp. FDA-CDC-AR_0164]
MSEKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWRFVR

Download         Length: 219 bp

>T104472 NZ_CP028950:354962-355180 [Enterobacter cloacae complex sp. FDA-CDC-AR_0164]
ATGTCTGAAAAACCACTCACAAAAATCGATTATTTGATGCGTTTGCGACGCTGCCAGTCAATAGACACGCTTGAACGTGT
AATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCGGTATTTTATTCAGCGGCTGACCACCGTCTTGCTGAAC
TGACCATGAATAAGCTGTATGACAAAATCCCAACGTCCGTGTGGAGATTTGTCCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14495.31 Da        Isoelectric Point: 4.8886

>AT104472 WP_020885187.1 NZ_CP028950:354560-354934 [Enterobacter cloacae complex sp. FDA-CDC-AR_0164]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFINVSRANPVSLSC

Download         Length: 375 bp

>AT104472 NZ_CP028950:354560-354934 [Enterobacter cloacae complex sp. FDA-CDC-AR_0164]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGATGAAAGTAACCATGGCTGGGTAAACGACCCAACGTCTGCCATCAATTTACAGTTAAACGAGTTGATCGAGC
ATATTGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTGATTGAGCAAATTGATGAATACCTG
GATGACACCTTTATGTTGTTCAGCAGCTACGGCATTAATGCGCAAGATTTGCAGAAATGGCGTAAATCGGGCAACCGACT
ATTTCGTTGCTTCATCAACGTGAGCAGAGCTAACCCCGTTAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A839BM33

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A5C1BX74

References