104472

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 354560..355180 Replicon chromosome
Accession NZ_CP028950
Organism Enterobacter cloacae complex sp. FDA-CDC-AR_0164

Toxin (Protein)


Gene name Hha Uniprot ID G8LPY2
Locus tag AM410_RS01775 Protein ID WP_014168902.1
Coordinates 354962..355180 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID W0BRV6
Locus tag AM410_RS01770 Protein ID WP_020885187.1
Coordinates 354560..354934 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM410_RS01760 349686..350879 + 1194 WP_020885186.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
AM410_RS01765 350902..354048 + 3147 WP_014168904.1 multidrug efflux RND transporter permease subunit -
AM410_RS01770 354560..354934 + 375 WP_020885187.1 Hha toxicity modulator TomB Antitoxin
AM410_RS01775 354962..355180 + 219 WP_014168902.1 hemolysin expression modulator Hha Toxin
AM410_RS01780 355390..355941 + 552 WP_020885188.1 maltose O-acetyltransferase -
AM410_RS01785 356059..356526 + 468 WP_032677533.1 membrane protein -
AM410_RS01790 356498..357958 - 1461 WP_108647463.1 PLP-dependent aminotransferase family protein -
AM410_RS01795 358059..358769 + 711 WP_073395633.1 GNAT family N-acetyltransferase -
AM410_RS01800 358766..358906 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
AM410_RS01805 358909..359169 - 261 WP_010428154.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8654.04 Da        Isoelectric Point: 8.9107

>T104472 WP_014168902.1 NZ_CP028950:354962-355180 [Enterobacter cloacae complex sp. FDA-CDC-AR_0164]
MSEKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWRFVR

Download         Length: 219 bp

>T104472 NZ_CP028950:354962-355180 [Enterobacter cloacae complex sp. FDA-CDC-AR_0164]
ATGTCTGAAAAACCACTCACAAAAATCGATTATTTGATGCGTTTGCGACGCTGCCAGTCAATAGACACGCTTGAACGTGT
AATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCGGTATTTTATTCAGCGGCTGACCACCGTCTTGCTGAAC
TGACCATGAATAAGCTGTATGACAAAATCCCAACGTCCGTGTGGAGATTTGTCCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14495.31 Da        Isoelectric Point: 4.8886

>AT104472 WP_020885187.1 NZ_CP028950:354560-354934 [Enterobacter cloacae complex sp. FDA-CDC-AR_0164]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFINVSRANPVSLSC

Download         Length: 375 bp

>AT104472 NZ_CP028950:354560-354934 [Enterobacter cloacae complex sp. FDA-CDC-AR_0164]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGATGAAAGTAACCATGGCTGGGTAAACGACCCAACGTCTGCCATCAATTTACAGTTAAACGAGTTGATCGAGC
ATATTGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTGATTGAGCAAATTGATGAATACCTG
GATGACACCTTTATGTTGTTCAGCAGCTACGGCATTAATGCGCAAGATTTGCAGAAATGGCGTAAATCGGGCAACCGACT
ATTTCGTTGCTTCATCAACGTGAGCAGAGCTAACCCCGTTAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A839BM33

Antitoxin

Source ID Structure
AlphaFold DB A0A5C1BX74

References