Detailed information of TA system TA104468

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3344126..3344795
• Replicon: chromosome
• Accession: NZ_CP028949
• Organism: Serratia marcescens strain AR_0121

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A2V4FX75
• Locus tag: AM368_RS15900
• Protein ID: WP_033649453.1
• Coordinates: 3344373..3344795 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A8G2G4M4
• Locus tag: AM368_RS15895
• Protein ID: WP_004931679.1
• Coordinates: 3344126..3344392 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM368_RS15875	3340660..3341268	-	609	WP_048321922.1	HD domain-containing protein	-
AM368_RS15880	3341452..3342126	+	675	WP_033649450.1	hemolysin III family protein	-
AM368_RS15885	3342277..3342774	+	498	WP_033635831.1	DUF2165 domain-containing protein	-
AM368_RS15890	3342813..3343805	-	993	WP_048321921.1	tRNA-modifying protein YgfZ	-
AM368_RS15895	3344126..3344392	+	267	WP_004931679.1	FAD assembly factor SdhE	Antitoxin
AM368_RS15900	3344373..3344795	+	423	WP_033649453.1	protein YgfX	Toxin
AM368_RS15905	3344795..3345490	+	696	WP_033649454.1	two-component system response regulator CreB	-
AM368_RS15910	3345487..3346905	+	1419	WP_033649455.1	two-component system sensor histidine kinase CreC	-
AM368_RS15915	3346986..3348350	+	1365	WP_033649456.1	cell envelope integrity protein CreD	-
AM368_RS15920	3348388..3348906	-	519	WP_033635825.1	flavodoxin FldB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16471.59 Da
• Isoelectric Point: 10.8114

>T104468 WP_033649453.1 NZ_CP028949:3344373-3344795 [Serratia marcescens]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAAQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGMLLTLLPMEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPAGDGEDP

Nucleotide

• Length: 423 bp

>T104468 NZ_CP028949:3344373-3344795 [Serratia marcescens]
GTGGCCCAGTGGCGATGTGATATCCGCATTTCCTGGCGCACCCAGCTGTTTTCACTGTTGACCCACGGCGTGTTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAAGGTTTTGGCCCGCTCTGGCTGGTGCTGCTGACGCTGGTGGTGTTTCAGTGCA
TTCGCAGCCAGAAGCGCATCGCCGCGGCGCAGGGCGAGCTGCGGCTGCTGGCGGACCGGCGCTTCAGCTGGCACGGCCGC
GAGTGGCGGCTGGCGAAAAAACCGTGGATGCCGGGTTACGGCATGCTGCTGACGCTGCTGCCGATGGAGGGCAAAAAGCG
CCGCCGGCTGTGGCTGGCTTCCGACTGCATGAGCAAAGAGGAGTGGCGCCACCTGCGGCAGCTGTTGCTGTATCCGCCGG
CGGGTGACGGCGAGGATCCCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10387.89 Da
• Isoelectric Point: 4.7921

>AT104468 WP_004931679.1 NZ_CP028949:3344126-3344392 [Serratia marcescens]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDGELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT104468 NZ_CP028949:3344126-3344392 [Serratia marcescens]
ATGGATATTAACAACAAAGCACGAATTCACTGGGCTTGCCGCCGTGGCATGCGCGAGCTGGACATCTCCATCATGCCGTT
CTTCGAGTACGAATACGACAGCCTGAATGACGCGGACAAGGCGCTGTTTATCCGCCTGCTGGAGTGCGACGATCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCGCCGCAGGACGGCGAGCTGCAGAGAATGGTGACCCTGATCCAAACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA

Structures

Toxin

• AlphaFold DB: A0A2V4FX75