Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 2311933..2312468 Replicon chromosome
Accession NZ_CP028949
Organism Serratia marcescens strain AR_0121

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag AM368_RS11105 Protein ID WP_033649525.1
Coordinates 2311933..2312208 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag AM368_RS11110 Protein ID WP_033649526.1
Coordinates 2312208..2312468 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM368_RS11085 2307751..2308743 - 993 WP_033649523.1 acyltransferase -
AM368_RS11090 2308961..2310208 + 1248 WP_033649577.1 MFS transporter -
AM368_RS11095 2310262..2310888 - 627 WP_033649524.1 LysE family translocator -
AM368_RS11100 2311010..2311921 + 912 WP_033636572.1 LysR family transcriptional regulator -
AM368_RS11105 2311933..2312208 - 276 WP_033649525.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AM368_RS11110 2312208..2312468 - 261 WP_033649526.1 ribbon-helix-helix domain-containing protein Antitoxin
AM368_RS11115 2312551..2314392 - 1842 WP_033649527.1 selenocysteine-specific translation elongation factor -
AM368_RS11120 2314389..2315783 - 1395 WP_033649528.1 L-seryl-tRNA(Sec) selenium transferase -
AM368_RS11125 2315853..2316458 - 606 WP_033649529.1 glutathione S-transferase -
AM368_RS11130 2316499..2317149 - 651 WP_033649530.1 DcrB-related protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10596.34 Da        Isoelectric Point: 10.3377

>T104465 WP_033649525.1 NZ_CP028949:c2312208-2311933 [Serratia marcescens]
MELKWTSKALSDLARLFEFLALVNRTAAANSVKALVAAPKALLDNSRLGERLDEFLPQEVRRILVGRYEIRYQVQPATIY
VLRIWHTREER

Download         Length: 276 bp

>T104465 NZ_CP028949:c2312208-2311933 [Serratia marcescens]
ATGGAGTTAAAATGGACGAGTAAGGCGCTATCGGATTTGGCGCGTTTGTTTGAGTTTCTTGCCTTGGTTAACCGTACTGC
GGCAGCGAATTCGGTGAAGGCCTTGGTCGCCGCGCCTAAAGCGTTGCTTGATAATTCTCGCCTGGGTGAAAGACTGGACG
AGTTTTTACCGCAGGAAGTGAGGCGTATTCTGGTCGGCCGTTATGAGATACGTTACCAGGTGCAGCCGGCAACGATTTAT
GTTCTGCGTATTTGGCATACCCGCGAAGAGCGATAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9698.01 Da        Isoelectric Point: 4.5201

>AT104465 WP_033649526.1 NZ_CP028949:c2312468-2312208 [Serratia marcescens]
MNTKVITAHVPLPLAEKVDEMAAKLERSRGWIVKQALTAWLEQEEERRRLTLAALADVEQQNVIDHESVEAWAASLDSDD
PLPVPR

Download         Length: 261 bp

>AT104465 NZ_CP028949:c2312468-2312208 [Serratia marcescens]
ATGAATACGAAAGTCATCACCGCTCATGTCCCGCTGCCTTTGGCTGAAAAGGTGGATGAAATGGCCGCCAAACTTGAACG
CTCACGGGGATGGATAGTGAAGCAAGCCCTCACCGCCTGGCTCGAGCAAGAGGAAGAGCGTCGTCGGTTAACGCTGGCGG
CGCTGGCCGATGTCGAACAGCAAAACGTTATCGATCATGAATCGGTAGAAGCCTGGGCTGCCAGCCTGGACAGTGACGAT
CCGCTGCCGGTACCGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References