Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1287547..1288168 Replicon chromosome
Accession NZ_CP028949
Organism Serratia marcescens strain AR_0121

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4G7F9
Locus tag AM368_RS06230 Protein ID WP_004940313.1
Coordinates 1287965..1288168 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag AM368_RS06225 Protein ID WP_004940312.1
Coordinates 1287547..1287915 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM368_RS06195 1283642..1283896 + 255 WP_048321318.1 type B 50S ribosomal protein L31 -
AM368_RS06200 1283909..1284049 + 141 WP_004940304.1 type B 50S ribosomal protein L36 -
AM368_RS06205 1284156..1285034 - 879 WP_041033680.1 metal ABC transporter substrate-binding protein -
AM368_RS06210 1285060..1285917 - 858 WP_033637343.1 metal ABC transporter permease -
AM368_RS06215 1285914..1286627 - 714 WP_048321317.1 ABC transporter ATP-binding protein -
AM368_RS06220 1287035..1287388 + 354 WP_033647274.1 hypothetical protein -
AM368_RS06225 1287547..1287915 + 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
AM368_RS06230 1287965..1288168 + 204 WP_004940313.1 hemolysin expression modulator Hha Toxin
AM368_RS06235 1288465..1288983 - 519 WP_047568991.1 cytochrome b/b6 domain-containing protein -
AM368_RS06240 1289036..1290466 - 1431 WP_043146738.1 N-acetylglucosamine-binding protein GbpA -
AM368_RS06245 1290720..1291082 + 363 WP_033647278.1 type II secretion system pilot lipoprotein GspS -
AM368_RS06250 1291079..1291894 - 816 WP_048321316.1 A24 family peptidase -
AM368_RS06255 1291931..1292377 - 447 WP_039566985.1 type II secretion system protein M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8107.37 Da        Isoelectric Point: 6.9756

>T104462 WP_004940313.1 NZ_CP028949:1287965-1288168 [Serratia marcescens]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T104462 NZ_CP028949:1287965-1288168 [Serratia marcescens]
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATTGAGAAAAATAA
GTACGAGCTTTCCGATGATGAACTGGAGCTGTTTTACTCAGCGGCCGATCACCGTCTGGCGGAGCTCACCATGAACAAAC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT104462 WP_004940312.1 NZ_CP028949:1287547-1287915 [Serratia marcescens]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT104462 NZ_CP028949:1287547-1287915 [Serratia marcescens]
ATGGATGAGTATTCGCCTAAGCGACACGACATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
TACCCTGGGAGACAGTCACCATGGGTGGGTCAACGATCCGACGTCCTCCGTCAACCTGCAGCTTAATGAGTTGATCGAAC
ATATCGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAATCAGACCTGTCGGAGTTAGTCGAAGAATATCTC
GACGATACCTATACGCTGTTCAGCAGCTACGGTATCAATGATTCCGACCTGCGCCGCTGGCAAAAAACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4G7F9

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References