Detailed information of TA system TA104450

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 4901767..4902292
• Replicon: chromosome
• Accession: NZ_CP028948
• Organism: Serratia marcescens strain AR_0123

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: AM370_RS23265
• Protein ID: WP_033646666.1
• Coordinates: 4902008..4902292 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8B4GIN1
• Locus tag: AM370_RS23260
• Protein ID: WP_004928423.1
• Coordinates: 4901767..4902018 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM370_RS23230	4897038..4897580	+	543	WP_033637821.1	lipoprotein	-
AM370_RS23235	4897845..4898573	+	729	WP_038884338.1	arginine ABC transporter ATP-binding protein ArtP	-
AM370_RS23240	4898606..4899337	+	732	WP_039566746.1	arginine ABC transporter substrate-binding protein	-
AM370_RS23245	4899347..4900063	+	717	WP_033646665.1	arginine ABC transporter permease ArtQ	-
AM370_RS23250	4900063..4900731	+	669	WP_033637817.1	arginine ABC transporter permease ArtM	-
AM370_RS23255	4900931..4901665	+	735	WP_033637816.1	arginine ABC transporter substrate-binding protein	-
AM370_RS23260	4901767..4902018	+	252	WP_004928423.1	prevent-host-death protein	Antitoxin
AM370_RS23265	4902008..4902292	+	285	WP_033646666.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AM370_RS23270	4902289..4903416	-	1128	WP_033646667.1	23S rRNA (uracil(747)-C(5))-methyltransferase RlmC	-
AM370_RS23275	4903486..4903965	-	480	WP_048321404.1	YbjO family protein	-
AM370_RS23280	4904070..4904915	-	846	WP_016928360.1	putrescine ABC transporter permease PotI	-
AM370_RS23285	4904912..4905874	-	963	WP_033646669.1	putrescine ABC transporter permease PotH	-
AM370_RS23290	4905899..4907032	-	1134	WP_033637812.1	putrescine ABC transporter ATP-binding subunit PotG	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10797.98 Da
• Isoelectric Point: 10.7537

>T104450 WP_033646666.1 NZ_CP028948:4902008-4902292 [Serratia marcescens]
MTYKLEFEEHALKEFKKLSPVIREQFKKKLVSVLVNPHVPANKLAGLPDCYKIKLRASGFRLVYRVMETKIVVLVLSVGK
REHSAAYTAAKKRL

Nucleotide

• Length: 285 bp

>T104450 NZ_CP028948:4902008-4902292 [Serratia marcescens]
ATGACTTATAAGCTTGAATTCGAAGAACATGCGCTGAAGGAATTTAAAAAACTGTCCCCGGTGATCCGGGAACAGTTCAA
AAAAAAGCTGGTATCGGTATTGGTTAATCCCCACGTCCCCGCCAACAAACTCGCCGGTTTGCCCGATTGCTACAAAATCA
AACTCAGAGCATCAGGCTTTCGTTTGGTGTATCGCGTCATGGAAACGAAGATCGTGGTTCTGGTCCTGTCTGTGGGCAAA
CGCGAACATTCAGCGGCTTATACGGCTGCCAAAAAGCGCCTTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9108.39 Da
• Isoelectric Point: 4.5203

>AT104450 WP_004928423.1 NZ_CP028948:4901767-4902018 [Serratia marcescens]
MTVQPILADSAVSISDFKKSPNAALKEAQGQPVAVLTNGKISGYYVSPETWEAIAEYLEDIELAEIVRSRMNGKRIKVNL
DDL

Nucleotide

• Length: 252 bp

>AT104450 NZ_CP028948:4901767-4902018 [Serratia marcescens]
ATGACGGTTCAACCCATTCTTGCCGATTCCGCAGTCAGCATCAGCGATTTTAAGAAATCGCCCAACGCCGCCCTTAAAGA
GGCACAAGGGCAGCCGGTCGCCGTCCTGACCAACGGTAAGATTTCGGGATATTACGTCTCACCGGAAACCTGGGAGGCTA
TCGCGGAGTACCTGGAAGATATCGAACTCGCTGAAATCGTTCGTTCACGGATGAACGGCAAACGCATTAAGGTCAATTTG
GATGACTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A8B4GIN1