Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2823519..2824175 Replicon chromosome
Accession NZ_CP028948
Organism Serratia marcescens strain AR_0123

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag AM370_RS13415 Protein ID WP_033648839.1
Coordinates 2823786..2824175 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag AM370_RS13410 Protein ID WP_033648840.1
Coordinates 2823519..2823782 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM370_RS13390 2818600..2819649 - 1050 WP_033635553.1 class I fructose-bisphosphate aldolase -
AM370_RS13395 2819939..2820844 - 906 WP_033635546.1 lipid kinase YegS -
AM370_RS13400 2821308..2822660 - 1353 WP_033654556.1 tRNA 5-hydroxyuridine modification protein YegQ -
AM370_RS13405 2822841..2823179 - 339 WP_033648841.1 YegP family protein -
AM370_RS13410 2823519..2823782 + 264 WP_033648840.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
AM370_RS13415 2823786..2824175 + 390 WP_033648839.1 type II toxin-antitoxin system VapC family toxin Toxin
AM370_RS13420 2824183..2824899 - 717 WP_033635542.1 two-component system response regulator BaeR -
AM370_RS13425 2824899..2826281 - 1383 WP_033635541.1 two-component system sensor histidine kinase BaeS -
AM370_RS13430 2826278..2827708 - 1431 WP_043147820.1 multidrug transporter subunit MdtD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14277.50 Da        Isoelectric Point: 7.8786

>T104440 WP_033648839.1 NZ_CP028948:2823786-2824175 [Serratia marcescens]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELLYGVAKRRNKALQSVVEAFLAAVTVYAWDSEAARCYGEM
RANMEKKGKIMGALDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Download         Length: 390 bp

>T104440 NZ_CP028948:2823786-2824175 [Serratia marcescens]
ATGTACATGTTTGATACCAACACCGTCAGCCACTTGTTTCGGCAGCATCCGCAGGTGCTTAACGTCATGGAAAAGCTCCC
GCCTTCTGCCGTATGTATTTCCAGCGTCACGGAGGCGGAACTGCTTTACGGTGTGGCTAAACGGCGGAACAAGGCGTTGC
AAAGCGTGGTCGAGGCCTTTCTTGCCGCGGTGACGGTCTATGCATGGGATAGCGAGGCCGCCCGCTGCTACGGTGAAATG
CGCGCGAACATGGAGAAAAAGGGCAAAATCATGGGCGCGCTGGATCAACTGATCGCCGCGCACGCGCAGAGCCGTGGCGC
GACGCTGGTGACCAACGATCGCGCATTCGCCATGGTGCCCGGGTTGGCGGTTGAAGACTGGACGCGCTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10032.29 Da        Isoelectric Point: 4.6702

>AT104440 WP_033648840.1 NZ_CP028948:2823519-2823782 [Serratia marcescens]
MERIAKLFKNGRNQAVRLPVEFEFDADRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Download         Length: 264 bp

>AT104440 NZ_CP028948:2823519-2823782 [Serratia marcescens]
ATGGAAAGAATCGCAAAGCTGTTTAAAAACGGCAGAAATCAGGCGGTGAGGTTACCGGTGGAATTTGAATTTGATGCGGA
TCGTGTCTATATCCGTCGCGATCGGGAGGGCAACGTGATTTTATCCAAATATCCGGCAAAGCCGGACAGCTGGGCACCGC
TGCTGAGCATTATCGCCCAAACGCCGGTGCCACAAGAGTTTCTTGGCGCGGAAGATCGTCAGCAAGGGGTTGCAGACCGC
GATCCATTCTCAGAGGAAGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References