Detailed information of TA system TA104437

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 2155758..2156353
• Replicon: chromosome
• Accession: NZ_CP028948
• Organism: Serratia marcescens strain AR_0123

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: AM370_RS10280
• Protein ID: WP_072071906.1
• Coordinates: 2155758..2156012 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: AM370_RS10285
• Protein ID: WP_033633573.1
• Coordinates: 2156012..2156353 (+)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM370_RS10265	2152125..2152337	+	213	WP_072071909.1	hypothetical protein	-
AM370_RS10270	2152498..2154294	+	1797	WP_072071908.1	type I restriction-modification system subunit M	-
AM370_RS10275	2154291..2155373	+	1083	WP_072071907.1	restriction endonuclease	-
AM370_RS10280	2155758..2156012	+	255	WP_072071906.1	type II toxin-antitoxin system HicA family toxin	Toxin
AM370_RS10285	2156012..2156353	+	342	WP_033633573.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
AM370_RS10290	2156398..2157432	-	1035	WP_048321966.1	phage portal protein	-
AM370_RS10295	2157432..2159204	-	1773	WP_033632041.1	terminase ATPase subunit family protein	-
AM370_RS10300	2159347..2160162	+	816	WP_048321965.1	GPO family capsid scaffolding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	aac(6')-Ic	rfaE	2143634..2202498	58864

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-81)

Antitoxin

• Uncharacterised protein family HicB (55-100)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9526.00 Da
• Isoelectric Point: 11.1073

>T104437 WP_072071906.1 NZ_CP028948:2155758-2156012 [Serratia marcescens]
MNKRHQKTLSDVFTRPVNGSIKWSDIEALFTALGAEIHEREGSRIAVLLKGEKRVFHRPHPRPTTDKGAVNSIRIWLDSL
GIKP

Nucleotide

• Length: 255 bp

>T104437 NZ_CP028948:2155758-2156012 [Serratia marcescens]
ATGAACAAACGACACCAAAAAACGCTGTCAGATGTGTTTACCCGGCCTGTCAACGGTTCTATAAAGTGGTCTGATATTGA
GGCGCTTTTTACCGCATTAGGGGCGGAGATTCACGAAAGGGAAGGTTCTAGGATCGCGGTGCTGTTGAAAGGTGAAAAAA
GAGTCTTTCACCGGCCACACCCCAGACCTACCACTGACAAGGGGGCGGTTAACTCCATTCGGATCTGGTTGGATAGCTTA
GGAATAAAACCATGA

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12399.90 Da
• Isoelectric Point: 4.5789

>AT104437 WP_033633573.1 NZ_CP028948:2156012-2156353 [Serratia marcescens]
MNNTLKIDGHTAVINFDPEIEMFRGEFVGLNGGADFYAYSVDELKKEGAISLAVFLDECHKDGIEPYKSYSGKVTTRLSP
ERHQALAIAAQATGQSINELLNEGVDLVIEKHS

Nucleotide

• Length: 342 bp

>AT104437 NZ_CP028948:2156012-2156353 [Serratia marcescens]
ATGAATAACACACTGAAAATTGACGGCCATACGGCCGTCATCAACTTCGACCCTGAAATTGAAATGTTCCGGGGCGAGTT
TGTCGGGCTGAATGGTGGCGCCGACTTCTACGCCTACAGCGTGGACGAGCTGAAGAAAGAAGGCGCGATCTCACTCGCGG
TCTTTCTCGATGAGTGCCATAAAGACGGCATCGAGCCTTACAAGTCGTACAGCGGCAAAGTAACCACCCGCCTGTCGCCG
GAACGCCATCAGGCGTTAGCTATTGCCGCACAGGCCACCGGGCAGTCGATTAATGAACTGCTGAATGAAGGTGTTGATCT
GGTTATCGAAAAGCATTCCTGA