Detailed information of TA system TA104422

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 3290997..3291522
• Replicon: chromosome
• Accession: NZ_CP028946
• Organism: Serratia marcescens strain AR_0124

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: AM371_RS15600
• Protein ID: WP_033646666.1
• Coordinates: 3290997..3291281 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8B4GIN1
• Locus tag: AM371_RS15605
• Protein ID: WP_004928423.1
• Coordinates: 3291271..3291522 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM371_RS15575	3286257..3287390	+	1134	WP_033637812.1	putrescine ABC transporter ATP-binding subunit PotG	-
AM371_RS15580	3287415..3288377	+	963	WP_033646669.1	putrescine ABC transporter permease PotH	-
AM371_RS15585	3288374..3289219	+	846	WP_016928360.1	putrescine ABC transporter permease PotI	-
AM371_RS15590	3289324..3289803	+	480	WP_048321404.1	YbjO family protein	-
AM371_RS15595	3289873..3291000	+	1128	WP_033646667.1	23S rRNA (uracil(747)-C(5))-methyltransferase RlmC	-
AM371_RS15600	3290997..3291281	-	285	WP_033646666.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AM371_RS15605	3291271..3291522	-	252	WP_004928423.1	prevent-host-death protein	Antitoxin
AM371_RS15610	3291624..3292358	-	735	WP_033637816.1	arginine ABC transporter substrate-binding protein	-
AM371_RS15615	3292558..3293226	-	669	WP_033637817.1	arginine ABC transporter permease ArtM	-
AM371_RS15620	3293226..3293942	-	717	WP_033646665.1	arginine ABC transporter permease ArtQ	-
AM371_RS15625	3293952..3294683	-	732	WP_039566746.1	arginine ABC transporter substrate-binding protein	-
AM371_RS15630	3294716..3295444	-	729	WP_038884338.1	arginine ABC transporter ATP-binding protein ArtP	-
AM371_RS15635	3295709..3296251	-	543	WP_033637821.1	lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10797.98 Da
• Isoelectric Point: 10.7537

>T104422 WP_033646666.1 NZ_CP028946:c3291281-3290997 [Serratia marcescens]
MTYKLEFEEHALKEFKKLSPVIREQFKKKLVSVLVNPHVPANKLAGLPDCYKIKLRASGFRLVYRVMETKIVVLVLSVGK
REHSAAYTAAKKRL

Nucleotide

• Length: 285 bp

>T104422 NZ_CP028946:c3291281-3290997 [Serratia marcescens]
ATGACTTATAAGCTTGAATTCGAAGAACATGCGCTGAAGGAATTTAAAAAACTGTCCCCGGTGATCCGGGAACAGTTCAA
AAAAAAGCTGGTATCGGTATTGGTTAATCCCCACGTCCCCGCCAACAAACTCGCCGGTTTGCCCGATTGCTACAAAATCA
AACTCAGAGCATCAGGCTTTCGTTTGGTGTATCGCGTCATGGAAACGAAGATCGTGGTTCTGGTCCTGTCTGTGGGCAAA
CGCGAACATTCAGCGGCTTATACGGCTGCCAAAAAGCGCCTTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9108.39 Da
• Isoelectric Point: 4.5203

>AT104422 WP_004928423.1 NZ_CP028946:c3291522-3291271 [Serratia marcescens]
MTVQPILADSAVSISDFKKSPNAALKEAQGQPVAVLTNGKISGYYVSPETWEAIAEYLEDIELAEIVRSRMNGKRIKVNL
DDL

Nucleotide

• Length: 252 bp

>AT104422 NZ_CP028946:c3291522-3291271 [Serratia marcescens]
ATGACGGTTCAACCCATTCTTGCCGATTCCGCAGTCAGCATCAGCGATTTTAAGAAATCGCCCAACGCCGCCCTTAAAGA
GGCACAAGGGCAGCCGGTCGCCGTCCTGACCAACGGTAAGATTTCGGGATATTACGTCTCACCGGAAACCTGGGAGGCTA
TCGCGGAGTACCTGGAAGATATCGAACTCGCTGAAATCGTTCGTTCACGGATGAACGGCAAACGCATTAAGGTCAATTTG
GATGACTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A8B4GIN1