Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2670796..2671417 Replicon chromosome
Accession NZ_CP028946
Organism Serratia marcescens strain AR_0124

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4G7F9
Locus tag AM371_RS12565 Protein ID WP_004940313.1
Coordinates 2670796..2670999 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag AM371_RS12570 Protein ID WP_004940312.1
Coordinates 2671049..2671417 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM371_RS12540 2666581..2667027 + 447 WP_085286346.1 type II secretion system protein M -
AM371_RS12545 2667064..2667879 + 816 WP_049235196.1 A24 family peptidase -
AM371_RS12550 2667876..2668238 - 363 WP_033647278.1 type II secretion system pilot lipoprotein GspS -
AM371_RS12555 2668492..2669928 + 1437 WP_085286347.1 N-acetylglucosamine-binding protein GbpA -
AM371_RS12560 2669981..2670499 + 519 WP_085286348.1 cytochrome b/b6 domain-containing protein -
AM371_RS12565 2670796..2670999 - 204 WP_004940313.1 hemolysin expression modulator Hha Toxin
AM371_RS12570 2671049..2671417 - 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
AM371_RS12575 2671576..2671929 - 354 WP_033647274.1 hypothetical protein -
AM371_RS12580 2672337..2673050 + 714 WP_048321317.1 ABC transporter ATP-binding protein -
AM371_RS12585 2673047..2673904 + 858 WP_033637343.1 metal ABC transporter permease -
AM371_RS12590 2673930..2674808 + 879 WP_041033680.1 metal ABC transporter substrate-binding protein -
AM371_RS12595 2674915..2675055 - 141 WP_004940304.1 type B 50S ribosomal protein L36 -
AM371_RS12600 2675068..2675322 - 255 WP_048321318.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8107.37 Da        Isoelectric Point: 6.9756

>T104420 WP_004940313.1 NZ_CP028946:c2670999-2670796 [Serratia marcescens]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T104420 NZ_CP028946:c2670999-2670796 [Serratia marcescens]
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATTGAGAAAAATAA
GTACGAGCTTTCCGATGATGAACTGGAGCTGTTTTACTCAGCGGCCGATCACCGTCTGGCGGAGCTCACCATGAACAAAC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT104420 WP_004940312.1 NZ_CP028946:c2671417-2671049 [Serratia marcescens]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT104420 NZ_CP028946:c2671417-2671049 [Serratia marcescens]
ATGGATGAGTATTCGCCTAAGCGACACGACATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
TACCCTGGGAGACAGTCACCATGGGTGGGTCAACGATCCGACGTCCTCCGTCAACCTGCAGCTTAATGAGTTGATCGAAC
ATATCGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAATCAGACCTGTCGGAGTTAGTCGAAGAATATCTC
GACGATACCTATACGCTGTTCAGCAGCTACGGTATCAATGATTCCGACCTGCGCCGCTGGCAAAAAACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4G7F9

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References