Detailed information of TA system TA104417

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1(toxin)
• Location: 1593237..1593838
• Replicon: chromosome
• Accession: NZ_CP028946
• Organism: Serratia marcescens strain AR_0124

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: AM371_RS07500
• Protein ID: WP_033636540.1
• Coordinates: 1593237..1593617 (-)
• Length: 127 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A086G6A0
• Locus tag: AM371_RS07505
• Protein ID: WP_004933932.1
• Coordinates: 1593617..1593838 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AM371_RS07475	1588490..1589770	+	1281	WP_085286593.1	DUF3748 domain-containing protein	-
AM371_RS07480	1589801..1590148	-	348	WP_085286592.1	YceK/YidQ family lipoprotein	-
AM371_RS07485	1590459..1590872	+	414	WP_004933919.1	heat shock chaperone IbpA	-
AM371_RS07490	1590973..1591401	+	429	WP_004933922.1	heat shock chaperone IbpB	-
AM371_RS07495	1591568..1593226	+	1659	WP_033649549.1	putative transporter	-
AM371_RS07500	1593237..1593617	-	381	WP_033636540.1	type II toxin-antitoxin system VapC family toxin	Toxin
AM371_RS07505	1593617..1593838	-	222	WP_004933932.1	ribbon-helix-helix domain-containing protein	Antitoxin
AM371_RS07510	1593914..1595164	-	1251	WP_033645138.1	valine--pyruvate transaminase	-
AM371_RS07515	1595300..1597363	-	2064	WP_085286591.1	alpha-amylase	-
AM371_RS24805	1597560..1597712	+	153	WP_019455508.1	hypothetical protein	-
AM371_RS07520	1597714..1598691	-	978	WP_085286590.1	glyoxylate/hydroxypyruvate reductase GhrB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-102)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-40)

Sequences

Toxin

Protein

• Length: 127 a.a.
• Molecular weight: 14185.53 Da
• Isoelectric Point: 7.3170

>T104417 WP_033636540.1 NZ_CP028946:c1593617-1593237 [Serratia marcescens]
MVAQRALFDTNILIDYLNGIPQAKDVLTEYHINPAISAITWMEVMVGAKKQGPALELKTRQFLGQFLLLPITDEVAERAV
ELRHSQHVKLPDAIIWATAQVGFRTLISRNPKDFGTDNGVLMPYRL

Nucleotide

• Length: 381 bp

>T104417 NZ_CP028946:c1593617-1593237 [Serratia marcescens]
ATGGTGGCTCAACGGGCGTTATTCGACACCAATATCCTGATCGATTATCTCAACGGCATTCCTCAAGCCAAAGACGTTCT
GACCGAATACCACATCAACCCGGCTATTAGCGCCATCACCTGGATGGAAGTGATGGTGGGTGCCAAAAAACAGGGGCCAG
CGCTGGAGCTGAAAACGCGCCAGTTTTTAGGGCAATTCCTGCTGCTGCCTATTACCGATGAAGTTGCCGAACGCGCCGTA
GAACTGCGCCACTCACAGCATGTGAAGCTGCCGGACGCCATTATCTGGGCCACCGCGCAGGTGGGGTTCCGAACGCTCAT
CTCCCGCAACCCCAAAGATTTTGGCACTGACAACGGCGTGTTAATGCCTTACCGGCTGTAG

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8593.53 Da
• Isoelectric Point: 4.4791

>AT104417 WP_004933932.1 NZ_CP028946:c1593838-1593617 [Serratia marcescens]
MTRIVIDLPEEDLRQLDNLKNIRHVPRAEIIRQAVSRYLTENHVEDPSNAFGLWSGAMGDGVDYENRQREEWE

Nucleotide

• Length: 222 bp

>AT104417 NZ_CP028946:c1593838-1593617 [Serratia marcescens]
ATGACTCGCATCGTGATCGATTTACCTGAAGAAGACCTGCGGCAGCTCGACAATCTGAAAAATATCCGCCACGTTCCCCG
GGCCGAAATCATCCGTCAGGCCGTCTCCCGTTATCTGACGGAGAACCACGTTGAAGATCCCAGCAATGCTTTCGGGCTCT
GGTCCGGGGCGATGGGCGATGGCGTAGACTACGAAAATCGTCAGCGCGAGGAGTGGGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A086G6A0