Detailed information of TA system TA104412

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ataRT/DUF1778(antitoxin)
• Location: 2548622..2549385
• Replicon: chromosome
• Accession: NZ_CP028943
• Organism: Vibrio sp. dhg

Toxin (Protein)

• Gene name: ataT
• Uniprot ID: -
• Locus tag: DBX26_RS11755
• Protein ID: WP_118119256.1
• Coordinates: 2548879..2549385 (+)
• Length: 169 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: -
• Locus tag: DBX26_RS11750
• Protein ID: WP_118119254.1
• Coordinates: 2548622..2548888 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DBX26_RS11730	2544323..2544835	-	513	WP_174234192.1	S26 family signal peptidase	-
DBX26_RS11735	2544819..2545166	-	348	WP_015066569.1	hypothetical protein	-
DBX26_RS11740	2545159..2547558	-	2400	WP_118119250.1	type IV secretion system protein TraC	-
DBX26_RS11745	2547558..2548253	-	696	WP_118119252.1	DsbC family protein	-
DBX26_RS11750	2548622..2548888	+	267	WP_118119254.1	DUF1778 domain-containing protein	Antitoxin
DBX26_RS11755	2548879..2549385	+	507	WP_118119256.1	GNAT family N-acetyltransferase	Toxin
DBX26_RS11760	2549426..2549812	-	387	WP_023584042.1	hypothetical protein	-
DBX26_RS11765	2549809..2550381	-	573	WP_145573985.1	type IV conjugative transfer system lipoprotein TraV	-
DBX26_RS11770	2550456..2551745	-	1290	WP_118119260.1	TraB/VirB10 family protein	-
DBX26_RS11775	2551748..2552644	-	897	WP_118119809.1	type-F conjugative transfer system secretin TraK	-
DBX26_RS11780	2552628..2553254	-	627	WP_118119262.1	pilus assembly protein	-
DBX26_RS11785	2553251..2553532	-	282	WP_000433891.1	type IV conjugative transfer system protein TraL	-
DBX26_RS11795	2553766..2554062	+	297	WP_118119264.1	HigA family addiction module antidote protein	-
DBX26_RS25485	2554068..2554223	+	156	WP_162889697.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2502150..2576861	74711

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (42-146)

Antitoxin

• Vibrio phage ICP1, Orf50 (8-83)

Sequences

Toxin

Protein

• Length: 169 a.a.
• Molecular weight: 18288.00 Da
• Isoelectric Point: 6.8531

>T104412 WP_118119256.1 NZ_CP028943:2548879-2549385 [Vibrio sp. dhg]
MGISAPTLLTDEHEINAFHCGIEELDTWLRKQALKSQKRGTARVYVVNDTDAHQVVGYYAIAMGSVSREQAFSSLRRNSP
DPIPMVILARLGVDNAYQGQGIAAGLLKDCIIRSVQAMNAVGGAGILVHAIDGSAQTFYKKFGFKESTFDPLVLMARICD
IEKSLSID

Nucleotide

• Length: 507 bp

>T104412 NZ_CP028943:2548879-2549385 [Vibrio sp. dhg]
TTGGGAATAAGTGCACCAACCCTACTCACTGATGAGCACGAGATTAACGCCTTTCACTGTGGCATTGAAGAACTCGATAC
TTGGTTAAGAAAACAGGCGTTAAAGAGTCAAAAGCGGGGAACCGCGAGAGTGTATGTGGTCAATGACACTGACGCCCATC
AAGTGGTCGGGTACTATGCCATTGCCATGGGATCGGTTTCCAGAGAGCAAGCTTTCAGTTCATTAAGAAGAAATAGTCCA
GATCCCATTCCCATGGTGATTCTAGCCAGGCTTGGAGTAGATAACGCCTATCAAGGTCAAGGCATTGCGGCAGGTCTTTT
AAAAGATTGTATCATTCGCTCAGTACAAGCAATGAACGCTGTCGGTGGAGCAGGAATCTTAGTCCATGCTATTGATGGTA
GTGCGCAAACGTTCTACAAGAAATTTGGCTTCAAAGAATCGACGTTTGATCCTTTAGTACTCATGGCAAGGATCTGCGAT
ATCGAAAAATCATTGTCGATAGACTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9968.49 Da
• Isoelectric Point: 7.0151

>AT104412 WP_118119254.1 NZ_CP028943:2548622-2548888 [Vibrio sp. dhg]
MATKTAPINMRVLPSVRDIIDAAASLKKVDRTVFIQQAALNEAHNVLAEQRDFVLEAKAFEAFDNELRAEPQTLEGMKNL
FKRKAPWE

Nucleotide

• Length: 267 bp

>AT104412 NZ_CP028943:2548622-2548888 [Vibrio sp. dhg]
ATGGCTACAAAGACAGCGCCAATCAACATGCGAGTACTGCCATCGGTAAGAGACATTATCGATGCCGCAGCAAGTTTAAA
AAAAGTTGATAGAACCGTATTCATTCAGCAAGCCGCGCTCAATGAAGCGCATAACGTACTGGCCGAACAGCGGGATTTTG
TTCTTGAAGCAAAAGCTTTTGAAGCGTTTGATAACGAACTTCGTGCTGAGCCACAGACTCTTGAAGGCATGAAAAATCTG
TTTAAAAGGAAAGCGCCTTGGGAATAA