Detailed information of TA system TA104410

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-MazE
• Location: 1778304..1778928
• Replicon: chromosome
• Accession: NZ_CP028941
• Organism: Polynucleobacter sp. LimPoW16

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: DCO16_RS09270
• Protein ID: WP_173943378.1
• Coordinates: 1778524..1778928 (+)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: DCO16_RS09265
• Protein ID: WP_173943377.1
• Coordinates: 1778304..1778534 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DCO16_RS09245	1773982..1774719	-	738	WP_173943374.1	sulfite exporter TauE/SafE family protein	-
DCO16_RS09250	1775185..1775325	-	141	WP_173943375.1	hypothetical protein	-
DCO16_RS09255	1775368..1776297	-	930	WP_173943376.1	tripartite tricarboxylate transporter substrate binding protein	-
DCO16_RS09260	1776375..1777481	-	1107	Protein_1808	mandelate racemase/muconate lactonizing enzyme family protein	-
DCO16_RS09265	1778304..1778534	+	231	WP_173943377.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
DCO16_RS09270	1778524..1778928	+	405	WP_173943378.1	PIN domain-containing protein	Toxin
DCO16_RS09275	1778959..1781541	-	2583	WP_173943854.1	RNA polymerase sigma factor RpoD	-
DCO16_RS09280	1781789..1783738	-	1950	WP_173943379.1	DNA primase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-122)

Antitoxin

• SpoVT-AbrB domain (5-48)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 15504.63 Da
• Isoelectric Point: 6.0793

>T104410 WP_173943378.1 NZ_CP028941:1778524-1778928 [Polynucleobacter sp. LimPoW16]
MNARKNFFDTNTLLYLLSDQSSKAEWVTQNLDQGSIISVQVLNEFTSVSIRKSKLLPKEIDEFLEQFIAICNVQAIDLDT
FASGREISRRYGYHHYDSMIIASALQSGCEKLYSEDMQHRQIIDKRLHIVNPFI

Nucleotide

• Length: 405 bp

>T104410 NZ_CP028941:1778524-1778928 [Polynucleobacter sp. LimPoW16]
ATGAACGCTAGGAAAAACTTTTTTGATACTAATACCCTACTCTACTTACTATCAGATCAATCAAGCAAAGCGGAATGGGT
AACCCAAAATCTGGACCAAGGAAGCATCATTAGCGTCCAAGTTCTCAATGAATTCACTTCAGTTAGCATAAGAAAAAGCA
AGCTTTTACCAAAAGAGATTGATGAGTTTTTGGAGCAATTTATAGCAATATGTAATGTTCAAGCAATTGACTTGGATACT
TTTGCATCGGGGCGAGAAATTTCAAGAAGGTATGGCTACCATCATTACGATTCAATGATCATCGCCTCTGCACTTCAATC
AGGATGTGAGAAGCTTTATTCAGAAGATATGCAGCACCGACAAATTATCGATAAGAGACTGCATATTGTGAATCCCTTCA
TTTAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8851.27 Da
• Isoelectric Point: 10.4689

>AT104410 WP_173943377.1 NZ_CP028941:1778304-1778534 [Polynucleobacter sp. LimPoW16]
MVISKWGNSLAIRLPAQIVEILNLKEGDDIEIDVASRSHFKIKKKPSAQERLMSLRKYRGRLPADFHFDRMDANER

Nucleotide

• Length: 231 bp

>AT104410 NZ_CP028941:1778304-1778534 [Polynucleobacter sp. LimPoW16]
ATGGTCATCTCAAAATGGGGTAATAGCCTAGCGATTCGGCTGCCAGCGCAGATAGTAGAAATCCTTAATCTCAAAGAAGG
TGACGATATTGAAATTGATGTTGCAAGTCGAAGCCATTTTAAAATCAAGAAGAAACCCTCTGCACAAGAGAGGCTTATGA
GTTTGCGAAAATATAGAGGTCGACTACCAGCTGACTTTCACTTTGATCGTATGGATGCCAATGAACGCTAG