Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 761229..761869 Replicon chromosome
Accession NZ_CP028941
Organism Polynucleobacter sp. LimPoW16

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DCO16_RS03960 Protein ID WP_173942451.1
Coordinates 761229..761630 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag DCO16_RS03965 Protein ID WP_173942452.1
Coordinates 761630..761869 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DCO16_RS03935 756481..757365 - 885 WP_173942446.1 DUF3108 domain-containing protein -
DCO16_RS03940 757660..758742 + 1083 WP_173942447.1 glycosyltransferase -
DCO16_RS03945 759387..760058 + 672 WP_173942448.1 tyrosine-type recombinase/integrase -
DCO16_RS03950 760158..760526 - 369 WP_173942449.1 hypothetical protein -
DCO16_RS03955 760986..761219 - 234 WP_173942450.1 hypothetical protein -
DCO16_RS03960 761229..761630 - 402 WP_173942451.1 tRNA(fMet)-specific endonuclease VapC Toxin
DCO16_RS03965 761630..761869 - 240 WP_173942452.1 antitoxin Antitoxin
DCO16_RS03970 762012..762353 - 342 WP_173942453.1 hypothetical protein -
DCO16_RS03975 762377..762907 - 531 WP_173942454.1 hypothetical protein -
DCO16_RS03980 763061..763198 - 138 WP_173942455.1 hypothetical protein -
DCO16_RS03985 763476..763709 - 234 WP_173942456.1 transcriptional regulator -
DCO16_RS03990 764029..764983 - 955 Protein_774 IS30 family transposase -
DCO16_RS03995 765013..765369 + 357 WP_173942457.1 SCP2 sterol-binding domain-containing protein -
DCO16_RS04000 765401..766615 - 1215 WP_173943763.1 CoA transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14873.24 Da        Isoelectric Point: 6.8813

>T104409 WP_173942451.1 NZ_CP028941:c761630-761229 [Polynucleobacter sp. LimPoW16]
MLKYLLDTNIVIYVLKRRPKEVLEVFNANASRMAISSITLSELIYGAEKSLNVDKNLEAIEDFISHLEVLSYDAKASQHY
GQIKAALGKKGEIIGENDIHIAAHAIGQGLILVSNNLREFKRVPNLALENWVL

Download         Length: 402 bp

>T104409 NZ_CP028941:c761630-761229 [Polynucleobacter sp. LimPoW16]
ATGCTCAAATATTTACTAGACACCAATATTGTTATCTACGTACTCAAACGTAGGCCTAAGGAAGTGCTGGAAGTTTTTAA
TGCCAATGCTAGTCGTATGGCAATTTCTAGTATTACCTTGTCAGAGTTAATTTACGGTGCAGAAAAAAGCCTTAACGTAG
ATAAAAATTTAGAAGCGATTGAAGACTTCATCAGCCATCTTGAGGTTCTATCTTATGACGCCAAGGCATCGCAGCACTAT
GGGCAAATTAAAGCTGCGTTAGGAAAAAAAGGGGAAATCATAGGAGAGAATGATATTCATATTGCAGCCCATGCTATTGG
CCAGGGCTTGATATTGGTAAGCAACAATTTACGAGAATTTAAAAGAGTTCCAAATTTAGCGCTAGAAAATTGGGTGCTTT
AG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9112.40 Da        Isoelectric Point: 6.3301

>AT104409 WP_173942452.1 NZ_CP028941:c761869-761630 [Polynucleobacter sp. LimPoW16]
MTIAITTVFTNNRSQAVRMPAEARLPDEVKKVIVRIRGRERIITPIENTWDNFFLNGPTVSDDFLNERGVQKPAEREEL

Download         Length: 240 bp

>AT104409 NZ_CP028941:c761869-761630 [Polynucleobacter sp. LimPoW16]
ATGACTATAGCGATTACAACCGTGTTTACTAACAATCGAAGCCAGGCAGTCAGAATGCCCGCTGAAGCGCGTTTACCCGA
CGAAGTGAAAAAGGTGATCGTTCGCATTCGAGGTCGCGAACGCATCATTACGCCGATTGAAAATACGTGGGATAACTTTT
TCTTAAATGGCCCGACAGTATCTGATGACTTTTTGAATGAGCGCGGAGTACAAAAGCCAGCTGAGAGAGAAGAGCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References