Detailed information of TA system TA104403

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/Tad-HTH_37
• Location: 263139..263818
• Replicon: chromosome
• Accession: NZ_CP028941
• Organism: Polynucleobacter sp. LimPoW16

Toxin (Protein)

• Gene name: tad
• Uniprot ID: -
• Locus tag: DCO16_RS01480
• Protein ID: WP_173942019.1
• Coordinates: 263139..263501 (+)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: DCO16_RS01485
• Protein ID: WP_173942020.1
• Coordinates: 263498..263818 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DCO16_RS01440	258220..258705	+	486	WP_173942012.1	YajQ family cyclic di-GMP-binding protein	-
DCO16_RS01445	258820..260001	-	1182	WP_173942013.1	ATP-binding protein	-
DCO16_RS01455	260314..261228	+	915	WP_173942014.1	site-specific tyrosine recombinase XerD	-
DCO16_RS01460	261324..261533	+	210	WP_173942015.1	hypothetical protein	-
DCO16_RS01465	261533..261808	+	276	WP_173942016.1	type II toxin-antitoxin system RelE/ParE family toxin	-
DCO16_RS01470	261876..262520	+	645	WP_173942017.1	glycerol-3-phosphate 1-O-acyltransferase PlsY	-
DCO16_RS01475	262520..262891	+	372	WP_173942018.1	MAPEG family protein	-
DCO16_RS01480	263139..263501	+	363	WP_173942019.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DCO16_RS01485	263498..263818	+	321	WP_173942020.1	helix-turn-helix domain-containing protein	Antitoxin
DCO16_RS01490	263885..264679	+	795	WP_173942021.1	GTP cyclohydrolase I	-
DCO16_RS01495	265126..265401	+	276	WP_173942022.1	high-potential iron-sulfur protein	-
DCO16_RS01500	265508..266359	+	852	WP_173942023.1	YdcF family protein	-
DCO16_RS01505	266371..266988	+	618	WP_173942024.1	YqgE/AlgH family protein	-
DCO16_RS01510	266981..267448	+	468	WP_173942025.1	Holliday junction resolvase RuvX	-
DCO16_RS01515	267532..268197	-	666	WP_173942026.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
DCO16_RS01520	268204..268686	-	483	WP_173942027.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (16-109)

Antitoxin

• HigA2-like, helix-turn-helix domain (11-90)

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13290.54 Da
• Isoelectric Point: 9.8195

>T104403 WP_173942019.1 NZ_CP028941:263139-263501 [Polynucleobacter sp. LimPoW16]
MISSLKPLYWLGSSKKDLMALPEDVKDVFGYALHLSQCGKKHAQAKPLKGFNGASVLEVVEDHLGNTYRAVYTVKVANAV
YVLHCFQKKSTFGIQTPKPDMDLIAERLKIAQQHAKGSCK

Nucleotide

• Length: 363 bp

>T104403 NZ_CP028941:263139-263501 [Polynucleobacter sp. LimPoW16]
ATGATTAGCTCCTTAAAACCGCTTTATTGGCTCGGTTCTTCAAAAAAAGATTTAATGGCTTTGCCAGAAGATGTAAAAGA
TGTTTTTGGGTATGCTCTGCATTTATCTCAATGCGGTAAGAAGCATGCGCAAGCAAAACCTTTAAAGGGTTTTAATGGAG
CAAGTGTCCTAGAGGTTGTTGAGGATCACTTAGGAAATACGTACAGAGCGGTGTATACCGTTAAAGTGGCTAATGCGGTG
TATGTATTGCACTGTTTTCAAAAGAAATCAACTTTTGGTATACAGACCCCTAAGCCAGATATGGATCTTATTGCTGAGCG
ACTGAAAATAGCTCAGCAACATGCGAAAGGAAGTTGCAAATGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 11757.60 Da
• Isoelectric Point: 10.0982

>AT104403 WP_173942020.1 NZ_CP028941:263498-263818 [Polynucleobacter sp. LimPoW16]
MNQVEMSGGNIYADLGDPQAEEMLVKSRLAYKIGEIIKHRHLTQTDAAHLLGLTQPKLSGLLRGQFRGISEAKMLDCLNR
LGRDVDIVIRKRSRSQVSGHTSVVFA

Nucleotide

• Length: 321 bp

>AT104403 NZ_CP028941:263498-263818 [Polynucleobacter sp. LimPoW16]
ATGAATCAAGTTGAAATGAGTGGCGGCAATATCTATGCTGATCTTGGCGATCCTCAAGCGGAAGAGATGCTGGTTAAATC
TCGGCTGGCTTATAAGATTGGCGAAATCATCAAGCATCGCCATTTAACTCAGACTGATGCCGCACATCTTTTGGGGCTGA
CTCAACCTAAGCTGTCAGGGCTCTTAAGAGGTCAGTTTAGAGGTATTAGCGAAGCAAAAATGCTTGATTGTCTTAATCGT
CTGGGGCGGGATGTAGATATTGTGATTCGCAAACGCTCACGTTCTCAGGTTAGCGGTCACACTAGTGTGGTCTTTGCGTA
A