Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 100232..100896 Replicon chromosome
Accession NZ_CP028941
Organism Polynucleobacter sp. LimPoW16

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DCO16_RS00595 Protein ID WP_173941862.1
Coordinates 100492..100896 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag DCO16_RS00590 Protein ID WP_173943711.1
Coordinates 100232..100492 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DCO16_RS00550 95588..96175 + 588 WP_173941854.1 imidazoleglycerol-phosphate dehydratase HisB -
DCO16_RS00555 96241..96921 + 681 WP_173941855.1 imidazole glycerol phosphate synthase subunit HisH -
DCO16_RS00560 96941..97702 + 762 WP_173941856.1 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase -
DCO16_RS00565 97702..98460 + 759 WP_173941857.1 imidazole glycerol phosphate synthase subunit HisF -
DCO16_RS00570 98470..98862 - 393 WP_173941858.1 type II toxin-antitoxin system HicB family antitoxin -
DCO16_RS00575 99021..99275 + 255 WP_173941859.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
DCO16_RS00580 99275..99703 + 429 WP_173941860.1 type II toxin-antitoxin system VapC family toxin -
DCO16_RS00585 99758..100162 + 405 WP_173941861.1 phosphoribosyl-AMP cyclohydrolase -
DCO16_RS00590 100232..100492 + 261 WP_173943711.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
DCO16_RS00595 100492..100896 + 405 WP_173941862.1 type II toxin-antitoxin system VapC family toxin Toxin
DCO16_RS00600 100910..101311 + 402 WP_173941863.1 phosphoribosyl-ATP diphosphatase -
DCO16_RS00605 101304..101681 + 378 WP_173941864.1 histidine triad nucleotide-binding protein -
DCO16_RS00610 101698..101949 + 252 WP_173941865.1 Sec-independent protein translocase subunit TatA -
DCO16_RS00615 101991..102470 + 480 WP_173941866.1 Sec-independent protein translocase protein TatB -
DCO16_RS00620 102480..103334 + 855 WP_173941867.1 twin-arginine translocase subunit TatC -
DCO16_RS00625 103331..104871 - 1541 Protein_114 sel1 repeat family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-125)

Antitoxin

SpoVT-AbrB domain

(8-54)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15140.71 Da        Isoelectric Point: 9.5750

>T104402 WP_173941862.1 NZ_CP028941:100492-100896 [Polynucleobacter sp. LimPoW16]
MPAKRYMLDTNMVSGLIKQHPNIVRKITSIPMEQLCLSAISEGEILFGLAKKPQAKNLRRVVEEFLKRVDVLGWDSQVAE
RYGKLRADLELNGVLLGALDVQIAAHALSENTILVTNDQAFKRVKQLKIEDWTQ

Download         Length: 405 bp

>T104402 NZ_CP028941:100492-100896 [Polynucleobacter sp. LimPoW16]
ATGCCGGCTAAAAGATATATGCTTGACACCAATATGGTGAGTGGCCTGATAAAACAACACCCTAATATAGTGAGAAAGAT
TACTAGTATTCCTATGGAACAGCTGTGTTTATCGGCTATTTCTGAGGGAGAAATACTATTTGGCTTGGCTAAAAAACCTC
AAGCCAAGAACCTTCGTAGAGTAGTGGAAGAATTCTTAAAGCGAGTAGATGTTCTTGGGTGGGATAGTCAAGTTGCTGAG
CGTTATGGTAAGTTGAGGGCAGACTTAGAGCTAAATGGGGTGTTATTAGGGGCTTTAGATGTTCAAATCGCAGCGCATGC
TTTAAGCGAAAACACCATCTTAGTGACCAATGACCAAGCGTTTAAAAGGGTCAAGCAGTTAAAGATTGAAGATTGGACGC
AGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9836.14 Da        Isoelectric Point: 4.8096

>AT104402 WP_173943711.1 NZ_CP028941:100232-100492 [Polynucleobacter sp. LimPoW16]
MVQTAKIFMNGRSQAIRLPAAFRFDEKEVFIRKDPATGDLILSRKPDNWDGFFLALNQAEIPLGFLSAEERNQGIHNRDP
FEGLEE

Download         Length: 261 bp

>AT104402 NZ_CP028941:100232-100492 [Polynucleobacter sp. LimPoW16]
ATGGTCCAAACAGCAAAAATCTTCATGAATGGGCGTAGCCAGGCCATTCGGTTACCAGCAGCCTTTCGTTTTGATGAAAA
AGAAGTCTTTATTCGTAAAGATCCGGCTACTGGTGATTTGATTCTTTCACGTAAGCCCGATAACTGGGATGGTTTTTTCC
TTGCCTTGAATCAGGCTGAGATCCCACTAGGTTTTTTGTCAGCTGAGGAGCGCAATCAAGGTATTCATAATCGGGATCCT
TTTGAGGGCCTGGAAGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References