Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3407596..3408112 Replicon chromosome
Accession NZ_CP028932
Organism Klebsiella pneumoniae strain AR_0153

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag AM400_RS19855 Protein ID WP_004178374.1
Coordinates 3407828..3408112 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag AM400_RS19850 Protein ID WP_002886901.1
Coordinates 3407596..3407838 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM400_RS19835 3403624..3404364 + 741 WP_002886899.1 KDGP aldolase family protein -
AM400_RS19840 3404431..3405585 + 1155 WP_004178372.1 lactonase family protein -
AM400_RS19845 3405608..3407518 + 1911 WP_004178373.1 BglG family transcription antiterminator -
AM400_RS19850 3407596..3407838 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AM400_RS19855 3407828..3408112 + 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AM400_RS19860 3408116..3408580 - 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
AM400_RS19865 3408821..3410959 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
AM400_RS19870 3411316..3412059 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
AM400_RS29820 3412062..3412235 - 174 WP_032408826.1 hypothetical protein -
AM400_RS19875 3412320..3412628 + 309 WP_004178377.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T104390 WP_004178374.1 NZ_CP028932:3407828-3408112 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T104390 NZ_CP028932:3407828-3408112 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT104390 WP_002886901.1 NZ_CP028932:3407596-3407838 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT104390 NZ_CP028932:3407596-3407838 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References