Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 1306540..1307166 Replicon chromosome
Accession NZ_CP028922
Organism Paenibacillus sp. CAA11

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag DCC85_RS05995 Protein ID WP_108464763.1
Coordinates 1306816..1307166 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag DCC85_RS05990 Protein ID WP_199910010.1
Coordinates 1306540..1306812 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DCC85_RS05970 1302148..1302567 - 420 WP_108464758.1 MarR family transcriptional regulator -
DCC85_RS05975 1302792..1303691 + 900 WP_108464759.1 AraC family transcriptional regulator -
DCC85_RS05980 1303803..1304903 + 1101 WP_108464760.1 outer membrane lipoprotein-sorting protein -
DCC85_RS05985 1305101..1306285 + 1185 WP_108464761.1 alanine racemase -
DCC85_RS05990 1306540..1306812 + 273 WP_199910010.1 ribbon-helix-helix protein, CopG family Antitoxin
DCC85_RS05995 1306816..1307166 + 351 WP_108464763.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DCC85_RS06000 1307388..1309625 + 2238 WP_108464764.1 RNA-binding transcriptional accessory protein -
DCC85_RS06005 1309927..1310709 - 783 WP_108464765.1 alpha/beta hydrolase -
DCC85_RS06010 1310908..1311042 - 135 WP_108464766.1 cortex morphogenetic protein CmpA -
DCC85_RS06015 1311119..1311481 - 363 WP_108464767.1 hydrolase/acyltransferase -
DCC85_RS06020 1311573..1312034 + 462 WP_108464768.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12747.74 Da        Isoelectric Point: 5.1284

>T104373 WP_108464763.1 NZ_CP028922:1306816-1307166 [Paenibacillus sp. CAA11]
MIVKRGDVFFADLSPVVGSEQGGVRPVLIIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAAAHGFDRDSVILLEQI
RTIDKQRLTDKITHLDEETMKKVDDALLISLGLIDF

Download         Length: 351 bp

>T104373 NZ_CP028922:1306816-1307166 [Paenibacillus sp. CAA11]
TTGATTGTCAAGCGCGGCGATGTTTTTTTTGCAGATCTCTCGCCTGTGGTGGGTTCCGAGCAGGGAGGGGTAAGACCGGT
GCTGATTATTCAGAACGATATCGGGAACCGATTTAGTCCGACTGCGATTGTGGCGGCCATTACGGCCCAGATCCAGAAGG
CTAAGCTGCCGACCCATGTTGAAATCGATGCGGCTGCGCACGGTTTTGACCGGGATTCGGTTATCTTGCTGGAGCAGATT
CGCACCATTGATAAGCAAAGATTGACAGATAAGATCACGCATCTGGACGAAGAGACGATGAAGAAAGTGGACGACGCTCT
TCTGATCAGTTTGGGCTTGATTGATTTTTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10471.04 Da        Isoelectric Point: 7.2041

>AT104373 WP_199910010.1 NZ_CP028922:1306540-1306812 [Paenibacillus sp. CAA11]
MQNTKRIMISLPDHLLQEVDGIARLENSNRSELIRQAMKLYLNERKKRFIRESMQRGYMEMAKINLSMASEAFHAEEDAD
STLDRLVSGV

Download         Length: 273 bp

>AT104373 NZ_CP028922:1306540-1306812 [Paenibacillus sp. CAA11]
ATGCAGAACACCAAAAGAATCATGATCAGCTTGCCGGATCATCTTCTGCAGGAAGTGGATGGGATTGCCCGGCTGGAGAA
TTCCAACCGCAGTGAGCTCATTAGGCAGGCCATGAAGCTCTATTTGAATGAGCGGAAGAAACGCTTTATTCGGGAATCCA
TGCAGCGCGGCTACATGGAGATGGCCAAGATTAATTTGTCTATGGCGTCCGAAGCGTTTCATGCGGAGGAAGATGCGGAC
AGCACTCTCGACCGCCTAGTAAGCGGGGTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References